| Mechanism of the antagonism by pralidoxime and 1,1-trimethylenebis(4-hydroxyiminomethylpyridinium) of the action of echothiphate on the intestine. | |
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MedLine Citation:
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PMID: 14463753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pralidoxime chloride (pyridine-2-aldoxime methochloride; Protopam Chloride) and 1,1'-trimethylenebis(4-hydroxyiminomethylpyridinium bromide) (TMB-4) antagonize the spasm of the isolated or intact small intestine of the rabbit caused by the anticholinesterase, echothiophate iodide (S-2-dimethylaminoethyl OO-diethyl phosphorothiolate methiodide; Phospholine Iodide). In vitro, both oximes also antagonize the spasm caused by acetylcholine. The quantitative relationships have been studied in comparison with the activity of atropine against echothiophate and acetylcholine. Echothiophate-treated intestine which is subjected to a concentration of oxime sufficient to cause 100% restoration of function (but not cholinesterase reactivation) will go back into spasm on washing out both drugs. Strips treated with a high concentration of oxime, sufficient to cause 100% reactivation of cholinesterase, exhibit normal control tone and motility after washing. It is concluded that pralidoxime and 1,1'-trimethylenebis(4-hydroxyiminomethylpyridinium bromide) have an anticholinergic action as well as the ability to reactivate cholinesterase and that this action plays a significant part in the initial recovery of function under the conditions of these experiments. |
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Authors:
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R A LEHMAN |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology and chemotherapy Volume: 18 ISSN: 0366-0826 ISO Abbreviation: Br J Pharmacol Chemother Publication Date: 1962 Apr |
Date Detail:
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Created Date: 1962-12-01 Completed Date: 1998-11-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0154627 Medline TA: Br J Pharmacol Chemother Country: Not Available |
Other Details:
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Languages: eng Pagination: 287-98 Citation Subset: OM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholinesterase Inhibitors* Hydroxylamines / pharmacology* Intestine, Small / pharmacology* Parasympatholytics / pharmacology* Pyridines / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Hydroxylamines; 0/Parasympatholytics; 0/Pyridines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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