| Mechanism of the alcohol cyclic pattern: role of the hypothalamic-pituitary-thyroid axis. | |
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MedLine Citation:
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PMID: 10898753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cause of the cycle of urinary alcohol levels (UALs) in rats fed ethanol continually at a fixed rate is unknown. Rats were fed ethanol intragastrically at a constant dose for 2 mo, and daily body temperatures and UALs were recorded. Body temperature cycled inversely to UAL, suggesting that the rate of metabolism could be mechanistically involved in the rate of ethanol elimination during the cycle. To document this, whole body O(2) consumption rate was monitored daily during the cycle. The rate of O(2) consumption correlated positively with the change in body temperature and negatively with the change in UAL. Since the metabolic rate responds to changes in body temperature, thyroid hormone levels were measured during the UAL cycle. T(4) levels correlated positively with the O(2) consumption rate and negatively with the UALs. In a second experiment using propylthiouracil treatment, UALs did not cycle and a fall in body temperature failed to stimulate an increase in the rate of ethanol elimination. Consequently, rats died of overdose. Likewise, in a third experiment using rats with severed pituitary stalks, UALs failed to cycle and rats died of overdose. From these observations it was concluded that the UAL cycle depends on an intact hypothalamic-pituitary-thyroid axis response to the ethanol-induced drop in body temperature by increasing the rate of ethanol elimination. |
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Authors:
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J Li; V Nguyen; B A French; A F Parlow; G L Su; P Fu; Q X Yuan; S W French |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 279 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-08-10 Completed Date: 2000-08-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G118-25 Citation Subset: IM |
Affiliation:
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Department of Pathology, Harbor-UCLA Medical Center, Torrance, California 90509, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Animals Antimetabolites / pharmacology Body Temperature / physiology Central Nervous System Depressants / pharmacokinetics, urine Endotoxins / blood Enteral Nutrition Ethanol / pharmacokinetics, urine Hypothalamo-Hypophyseal System / physiology* Interleukin-1 / blood Liver / enzymology Liver Cirrhosis, Alcoholic / metabolism*, physiopathology* Male Organ Size Oxygen Consumption / physiology Propylthiouracil / pharmacology Rats Rats, Wistar Thyroid Gland / physiology* Thyrotropin / blood Thyroxine / blood Tumor Necrosis Factor-alpha / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AA-8116/AA/NIAAA NIH HHS; AA-P50-11999/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 0/Central Nervous System Depressants; 0/Endotoxins; 0/Interleukin-1; 0/Tumor Necrosis Factor-alpha; 51-52-5/Propylthiouracil; 64-17-5/Ethanol; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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