Document Detail


Mechanism of acute lung injury caused by inhalation of fabric protector and the effect of surfactant replacement.
MedLine Citation:
PMID:  9503223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the role of surfactant in the mechanism and treatment of acute lung injury caused by inhalation of fabric protector. DESIGN: Prospective, randomized study. SETTING: University laboratory. INTERVENTIONS: In vitro experiment: a porcine surfactant suspension (10 mg.ml-1) was exposed to a fabric protector aerosolized with an ultrasonic nebulizer for 1 min. Minimum surface tension (gamma min) was sequentially measured using pulsating bubble equipment. Animal experiment: 14 adult rats were anesthetized with pentobarbital and mechanically ventilated with pure oxygen. Then, all rats inhaled fabric protector aerosolized with the nebulizer for five breaths. Three hours after inhalation, the rats were randomly assigned to two groups: a surfactant group (n = 7), in which surfactant (100 mg.kg-1) was replaced, and a control group (n = 7), in which no substance was given. MEASUREMENTS AND RESULTS: In vitro experiment: exposure to fabric protector aerosol increased the mean gamma min of the surfactant from 1.7 to 19.2 mN.m-1 (n = 5, p < 0.05). Animal experiment; the mean partial pressure of oxygen in arterial blood (PaO2) in all rats decreased from 62.8 to 17.1 kPa at 3 h after inhalation. The PaO2 in the surfactant group increased to 49.8 +/- 11.1 (SD) kPa at 30 min after surfactant replacement (p < 0.05), while the PaO2 in the control group remained below 20 kPa. CONCLUSIONS: Impairment of surfactant is a factor involved in the development of acute lung injury caused by inhalation of fabric protector. Surfactant replacement may be therapeutic for such injuries.
Authors:
K Tashiro; Y Matsumoto; K Nishizuka; K Shibata; K Yamamoto; M Yamashita; T Kobayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  24     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-05-04     Completed Date:  1998-05-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, School of Medicine, Kanazawa University, Japan. tashirk@med.kanazawa-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acetates / adverse effects*
Alkanes / adverse effects*
Animals
Inhalation Exposure / adverse effects*
Lung / drug effects*
Lung Injury*
Prospective Studies
Pulmonary Surfactants / therapeutic use*
Random Allocation
Rats
Respiratory Distress Syndrome, Adult / chemically induced*,  drug therapy*
Solvents / adverse effects*
Chemical
Reg. No./Substance:
0/Acetates; 0/Alkanes; 0/Pulmonary Surfactants; 0/Solvents; 141-78-6/ethyl acetate; 8030-30-6/naphtha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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