| Mechanism of action of sacral nerve stimulation using a transdermal amplitude-modulated signal in a spinal cord injury rodent model. | |
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MedLine Citation:
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PMID: 23093526 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: : Sacral neuromodulation (SNM) is an effective treatment modality for several urological problems, including neurogenic bladder. However, the invasiveness of this technique makes it unsuitable for many patients. We present a novel transdermal amplitude-modulated signal (TAMS) that may provide a non-invasive alternative to implantable SNM to treat neurogenic detrusor overactivity (NDO). METHODS: : In this study, we investigated the mechanism of action of non-invasive SNM using TAMS on our established spinal cord injury (SCI) animal model. We demonstrated that spinally transected rats develop urinary bladder hyper-reflexia after 3 weeks of SCI, indicated by the presence of uninhibited contractions, increased resting pressure, increased threshold pressure and increased maximum voiding pressure. RESULTS: : Short-term neurostimulation affected urodynamics parameters by significantly reducing the threshold pressure (p = 0.02). Spinal transection also increased calcitonin gene-related protein (CGRP) concentration in the L6 dorsal root ganglia; whereas, neurostimulation significantly reduced CGRP concentration in L6 (p = 0.03). CONCLUSION: : TAMS caused a reduction in NDO by inhibiting C-fibre activity. |
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Authors:
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Mohamed S Elkelini; Igor Pravdivyi; Magdy M Hassouna |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian Urological Association journal = Journal de l'Association des urologues du Canada Volume: 6 ISSN: 1911-6470 ISO Abbreviation: Can Urol Assoc J Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-10-24 Completed Date: 2012-10-25 Revised Date: 2013-03-21 |
Medline Journal Info:
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Nlm Unique ID: 101312644 Medline TA: Can Urol Assoc J Country: Canada |
Other Details:
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Languages: eng Pagination: 227-30 Citation Subset: - |
Affiliation:
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Toronto Western Research Institute, Toronto, ON; Institute of Medical Science, University of Toronto and Department of Surgery, Division of Urology, University of Toronto, Toronto, ON. |
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