Document Detail

Mechanism of action of sacral nerve stimulation using a transdermal amplitude-modulated signal in a spinal cord injury rodent model.
MedLine Citation:
PMID:  23093526     Owner:  NLM     Status:  PubMed-not-MEDLINE    
INTRODUCTION: : Sacral neuromodulation (SNM) is an effective treatment modality for several urological problems, including neurogenic bladder. However, the invasiveness of this technique makes it unsuitable for many patients. We present a novel transdermal amplitude-modulated signal (TAMS) that may provide a non-invasive alternative to implantable SNM to treat neurogenic detrusor overactivity (NDO).
METHODS: : In this study, we investigated the mechanism of action of non-invasive SNM using TAMS on our established spinal cord injury (SCI) animal model. We demonstrated that spinally transected rats develop urinary bladder hyper-reflexia after 3 weeks of SCI, indicated by the presence of uninhibited contractions, increased resting pressure, increased threshold pressure and increased maximum voiding pressure.
RESULTS: : Short-term neurostimulation affected urodynamics parameters by significantly reducing the threshold pressure (p = 0.02). Spinal transection also increased calcitonin gene-related protein (CGRP) concentration in the L6 dorsal root ganglia; whereas, neurostimulation significantly reduced CGRP concentration in L6 (p = 0.03).
CONCLUSION: : TAMS caused a reduction in NDO by inhibiting C-fibre activity.
Mohamed S Elkelini; Igor Pravdivyi; Magdy M Hassouna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Urological Association journal = Journal de l'Association des urologues du Canada     Volume:  6     ISSN:  1911-6470     ISO Abbreviation:  Can Urol Assoc J     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-24     Completed Date:  2012-10-25     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  101312644     Medline TA:  Can Urol Assoc J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  227-30     Citation Subset:  -    
Toronto Western Research Institute, Toronto, ON; Institute of Medical Science, University of Toronto and Department of Surgery, Division of Urology, University of Toronto, Toronto, ON.
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