| Mechanism of action of an orally active PGE1-analogue in pregnant guinea-pigs. | |
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MedLine Citation:
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PMID: 7221013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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At the 43rd day of pregnancy 6 Experimental guinea-pigs were treated orally with the PGE1-analogue, CP 48,630 (Pfizer), while 6 animals served as vehicle Controls. An average dose of 1.5 mg CP 48,630 compromized the conceptus and provoked abortion in 6.6 +/- 1.4 hours in all 6 Experimental guinea-pigs. The vehicle Controls, with all pregnancies continuing intact, had high P-levels in peripheral and uterine vein plasma, ovaries, placenta and uterine tissue and low PGF-levels in the uterine vein plasma. In contrast, in the Experimental animals the P-levels were significantly reduced and the PGF-levels elevated. Thus, the "PG-Impact" rapidly tipped the regulatory balance of pregnancy, compromized the conceptus (all fetuses were dead and the placentae discolored), and provoked the evolution of uterine activity culminating in abortion. |
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Authors:
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W Elger; J Eskola; A I Csapo |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Prostaglandins Volume: 21 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-06-23 Completed Date: 1981-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 259-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced* Administration, Oral Animals Female Guinea Pigs Pregnancy Progesterone / blood Prostaglandins E, Synthetic / metabolism* Prostaglandins F / blood Uterus / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E, Synthetic; 0/Prostaglandins F; 57-83-0/Progesterone; 77107-52-9/CP 48630 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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