Document Detail

Mechanism of action of an orally active PGE1-analogue in pregnant guinea-pigs.
MedLine Citation:
PMID:  7221013     Owner:  NLM     Status:  MEDLINE    
At the 43rd day of pregnancy 6 Experimental guinea-pigs were treated orally with the PGE1-analogue, CP 48,630 (Pfizer), while 6 animals served as vehicle Controls. An average dose of 1.5 mg CP 48,630 compromized the conceptus and provoked abortion in 6.6 +/- 1.4 hours in all 6 Experimental guinea-pigs. The vehicle Controls, with all pregnancies continuing intact, had high P-levels in peripheral and uterine vein plasma, ovaries, placenta and uterine tissue and low PGF-levels in the uterine vein plasma. In contrast, in the Experimental animals the P-levels were significantly reduced and the PGF-levels elevated. Thus, the "PG-Impact" rapidly tipped the regulatory balance of pregnancy, compromized the conceptus (all fetuses were dead and the placentae discolored), and provoked the evolution of uterine activity culminating in abortion.
W Elger; J Eskola; A I Csapo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Prostaglandins     Volume:  21     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
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MeSH Terms
Abortion, Induced*
Administration, Oral
Guinea Pigs
Progesterone / blood
Prostaglandins E, Synthetic / metabolism*
Prostaglandins F / blood
Uterus / drug effects*
Reg. No./Substance:
0/Prostaglandins E, Synthetic; 0/Prostaglandins F; 57-83-0/Progesterone; 77107-52-9/CP 48630

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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