Document Detail


Mechanism of action of indomethacin in indomethacin-responsive headaches.
MedLine Citation:
PMID:  23423598     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Indomethacin, as a member of the non-steroidal anti-inflammatory drug class, plays a special role in the treatment of headaches. By definition, it is completely efficacious in the treatment of the primary headache disorders paroxysmal hemicrania and hemicrania continua. Therefore, indomethacin is also used as a tool for differential diagnosis in headache clinics. Indomethacin has a clear action as a cyclooxygenase inhibitor. Additional mechanisms and interactions with cell signaling pathways and inflammatory pathways are considered in this article. However, it is not known what mechanism or interaction with pathophysiological mechanisms is the key to indomethacin's specific pharmacology in headache therapy. Focusing on headache therapy, we summarize the current knowledge of pharmacology, treatment options, and recommendations for the use of indomethacin in primary headaches. New findings from the field of headache research, as well as from Alzheimer's disease and cancer research on the pharmacological actions of indomethacin and their potential implications on the pathophysiology of indomethacin sensitive headaches, are discussed.
Authors:
Oliver Summ; Stefan Evers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current pain and headache reports     Volume:  17     ISSN:  1534-3081     ISO Abbreviation:  Curr Pain Headache Rep     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100970666     Medline TA:  Curr Pain Headache Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327     Citation Subset:  IM    
Affiliation:
Department of Neurology, University-Hospital Münster, Albert-Schweitzer-Campus 1, A 1, 48149, Münster, Germany, osumm@uni-muenster.de.
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