| Mechanism of Visceral Fat Reduction in Tsumura Suzuki Obese, Diabetes (TSOD) Mice Orally Administered β-Cryptoxanthin from Satsuma Mandarin Oranges ( Citrus unshiu Marc). | |
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MedLine Citation:
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PMID: 22085304 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The carotenoid β-cryptoxanthin (β-CRX) is abundant in Satsuma mandarins ( Citrus unshiu Marc). Several studies have shown a relationship between Satsuma mandarin consumption and a low risk of several diseases, for example, diabetes, gout, and hypertension, suggesting β-CRX involvement in disease prevention. We investigated the effect of β-CRX on mildly obese males. β-CRX administration reduced visceral adipose tissue, body weight, and abdominal circumference. However, the detailed mechanism by which β-CRX mediates these changes remains unknown. To identify this mechanism, we used an obese model mouse (TSOD). Oral β-CRX administration repressed body weight, abdominal adipose tissue weight, and serum lipid concentrations in TSOD; these results are identical to previous human trial results. β-CRX administration significantly repressed adipocyte hypertrophy. Gene expression analysis strongly indicated that β-CRX can alter cytokine secretion and cell proliferation. These results suggest that β-CRX derived from Satsuma mandarins can help prevent obesity by repressing hypertrophy of abdominal adipocytes. |
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Authors:
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Katsuhiko Takayanagi; Sho-Ichi Morimoto; Yoshiyuki Shirakura; Katsuyuki Mukai; Toshie Sugiyama; Yoshihiko Tokuji; Masao Ohnishi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-15 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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R&D Center, UNITIKA Ltd. , 23 Uji-Kozakura, Uji, Kyoto 611-0021, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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