Document Detail

Mechanism of UVB-induced wrinkling of the skin: paracrine cytokine linkage between keratinocytes and fibroblasts leading to the stimulation of elastase.
MedLine Citation:
PMID:  19675551     Owner:  NLM     Status:  MEDLINE    
In clinical studies, the formation of facial wrinkles has been closely linked to the loss of elastic properties of the skin. Repetitive irradiation of animal skin with UVB radiation at suberythemal doses significantly reduces its elastic properties, resulting in the formation of wrinkles. Repetitive UVB irradiation elicits a marked alteration in the three-dimensional structure of elastic fibers, which is closely associated with a subsequent reduction in the elastic properties of the skin. Although UVB irradiation stimulates the activity of fibroblast elastases in the dermis, a synthetic inhibitor specific for fibroblast elastases prevents wrinkle formation. The close interrelationships among wrinkle formation, elastic properties, and elastic fiber linearity are revealed by the effects of different concentrations of the elastase inhibitor (R(2)>0.9), suggesting that enhanced elastase activity by dermal fibroblasts plays a pivotal role in the UVB wrinkling mechanism. In in vitro studies we identified a paracrine linkage between keratinocytes and fibroblasts that leads to wrinkle formation through the upregulation of fibroblast elastases. These studies support our hypothesis for a mechanism of wrinkle formation by which cytokine expression is activated in epidermal keratinocytes by UVB radiation and triggers dermal fibroblasts to increase their expression of elastase.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 36-43; doi:10.1038/jidsymp.2009.11.
Genji Imokawa
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research     Volume:  14     ISSN:  1529-1774     ISO Abbreviation:  J. Investig. Dermatol. Symp. Proc.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609059     Medline TA:  J Investig Dermatol Symp Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  36-43     Citation Subset:  IM    
School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan.
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MeSH Terms
Cytokines / metabolism
Elastic Tissue / physiology,  radiation effects
Elasticity / drug effects,  physiology,  radiation effects
Enzyme Inhibitors / pharmacology
Fibroblasts / pathology,  physiology,  radiation effects
Keratinocytes / pathology,  physiology,  radiation effects
Microscopy, Electron, Scanning
Pancreatic Elastase / antagonists & inhibitors,  metabolism
Paracrine Communication / radiation effects
Skin Aging / drug effects,  pathology,  physiology,  radiation effects*
Ultraviolet Rays / adverse effects*
Up-Regulation / radiation effects
Reg. No./Substance:
0/Cytokines; 0/Enzyme Inhibitors; EC Elastase

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