Document Detail


Mechanism of T cell exhaustion in a chronic environment.
MedLine Citation:
PMID:  21524346     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
T cell exhaustion develops under conditions of antigenpersistence caused by infection with various chronic pathogens, such as human immunodeficiency virus (HIV) and mycobacterium tuberculosis (TB), or by the development of cancer. T cell exhaustion is characterized by stepwise and progressive loss of T cell function, which is probably the main reason for the failed immunological control of chronic pathogens and cancers. Recent observations have detailed some of the intrinsic and extrinsic factors that influence the severity of T cell exhaustion. Duration and magnitude of antigenic activation of T cells might be associated with up-regulation of inhibitory receptors, which is a major intrinsic factor of T cell exhaustion. Extrinsic factors might include the production of suppressive cytokines, T cell priming by either non-professional antigenpresenting cells (APCs) or tolerogenic dendritic cells (DCs), and alteration of regulatory T (Treg) cells. Further investigation of the cellular and molecular processes behind the development of T cell exhaustion can reveal therapeutic targets and strategies for the treatment of chronic infections and cancers. Here, we report the properties and the mechanisms of T cell exhaustion in a chronic environment. [BMB reports 2011; 44(4): 217-231].
Authors:
Hyun-Tak Jin; Yun Hee Jeong; Hyo Jin Park; Sang-Jun Ha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BMB reports     Volume:  44     ISSN:  1976-670X     ISO Abbreviation:  BMB Rep     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465334     Medline TA:  BMB Rep     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  217-31     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, College of Life Science and Engineering, Yonsei University, Seoul 120-749, Korea sjha@yonsei.ac.kr.
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