Document Detail

On the Mechanism of Eukaryotic Cell Penetration by α- and β-Oligoarginines - Targeting Infected Erythro-cytes.
MedLine Citation:
PMID:  21259419     Owner:  NLM     Status:  In-Data-Review    
Fluorescein-labeled α- and β-octaarginine amides were synthesized. The route, by which these oligoarginine (OA) derivatives enter cells (hepatocytes, fibroblasts, macrophages), was investigated by confocal fluorescence microscopy. Comparisons (by co-localization experiments) with compounds of known penetration modes revealed that the β-octaarginine amide also uses multiple pathways to enter cells. There was no difference between the α- and the β-OAs. Like other cell-penetrating peptides (CPPs), the β-octaarginine eventually winds up in the nucleoli of the cell nuclei (cf. Chem. Biodiversity, 2004, 1, 65). Surprisingly, there was no entry of α- or β-OA into intact and healthy human erythrocytes (which do not possess a nucleus). Blood cells infected by Plasmodium falciparum (malaria parasite) were, however, entered readily, and the OAs went all the way through a couple of membranes into the parasite. The potential of these results for delivering specific antimalarial drugs directly into the parasite is discussed.
Faustin Kamena; Bopanna Monnanda; Danielle Makou; Stefania Capone; Krystyna Patora-Komisarska; Dieter Seebach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  8     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.
Max-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Free University Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, D-14195 Berlin, (phone: +49-30-83859573; fax: +49-30-83859302).
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