Document Detail

Mechanism of ECG changes and arrhythmogenic properties of low osmolality contrast media during coronary arteriography in dog.
MedLine Citation:
PMID:  2346966     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: The aim of the study was to investigate the mechanisms behind ECG changes and ventricular arrhythmias during coronary arteriography.
DESIGN: Transmembrane action potentials were recorded from isolated heart muscle preparations superfused with contrast media. Conductivity of plasma diluted with contrast media was determined in vitro. Epicardial ECG recordings were made during coronary arteriography.
SUBJECTS: Epicardial ECG recordings were made in eight mongrel dogs of either sex, weight 14-22 kg. Atrial appendages were excised from the same dogs and used for heart muscle preparation studies.
MEASUREMENTS AND MAIN RESULTS: Iohexol and ioxaglate affected the action potentials similarly: resting potential, amplitude, rate of depolarisation, and action potential duration increased; effective refractory period decreased. Both contrast media reduced plasma conductivity. During coronary arteriography both media increased R wave amplitude, depressed ST segment, and prolonged QT time on epicardial ECG.
CONCLUSIONS: ST segment deviation on ECG reflects hyperpolarization and increased amplitude of action potential rather than depolarisation consistent with ischaemia. Increased rate of depolarisation and amplitude of action potential together with reduced conductivity after contrast media may explain increased amplitude of QRS voltage on ECG. Observed regional changes in depolarisation, repolarisation, and refractoriness may be important in the genesis of ventricular arrhythmias.
N E Kløw; P M Tande; O Hevrøy; H Refsum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  24     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Coronary Angiography*
Electric Conductivity
Electrocardiography / drug effects*
Heart Rate / drug effects*
Iohexol / pharmacology*
Ioxaglic Acid / pharmacology*
Membrane Potentials / drug effects
Osmolar Concentration
Reg. No./Substance:
4419T9MX03/Iohexol; Z40X7EI2AF/Ioxaglic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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