Document Detail

Mechanics of ventilation with positive end-expiratory pressure.
MedLine Citation:
PMID:  327957     Owner:  NLM     Status:  MEDLINE    
The effect of graded increments in positive end-expiratory pressure (PEEP) on arterial oxygen partial pressure (PaO2) and shunt fraction (Qs/QT), oxygen delivery, and respiratory mechanics and work required to ventilate 8 critically ill patients is reported. The work required to ventilate the patients increases markedly with the application and progressive increase in the level of PEEP. However, improvement in lung mechanics lowers the net work of ventilating the lungs. At 20 cm H2O PEEP, the mean value for the work of ventilation in this group of patients is twice the mean value without PEEP. The increase in work of ventilation with PEEP is critical in the use of PEEP when patients are breathing spontaneously with or without intermittent mandatory ventilation.
C F Hobelmann; D E Smith; R W Virgilio; R M Peters
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  24     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-76     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Resistance
Cardiac Output
Lung Compliance
Middle Aged
Oxygen / blood
Positive-Pressure Respiration*
Respiratory Function Tests*
Work of Breathing
Reg. No./Substance:

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