Document Detail

Mechanical versus pharmacologic prevention of deep venous thrombosis.
MedLine Citation:
PMID:  7209773     Owner:  NLM     Status:  MEDLINE    
The prevention postoperatively of deep venous thrombosis was studied using three different regimens in 227 patients undergoing surgical procedures. Seventy-six patients received 5,000 units of heparin subcutaneously and 0.5 milligrams of dihydroergotamine twice a day. In 76 patients, intermittent pneumatic compression of the legs was applied preoperatively and postoperatively with active physiotherapy. The last 75 patients received subcutaneously 5,000 units of heparin each eight hours. Systematic deep venous thrombosis detection was carried out using both the 125I fibrinogen test and the Doppler method, being confirmed by phlebography if positive. The 125I fibrinogen test proved to be more sensitive and more specific. The incidence of deep venous thrombosis and pulmonary embolism were comparable in the groups, mechanical prophylaxis being as effective as the two other regimens. No side-effects were noted with the use of intermittent compression boots. A venoconstricting agent associated with heparin may permit smaller doses with the same prophylactic effect.
G Moser; B Krähenbühl; R Barroussel; J J Bene; A Donath; A Rohner
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  152     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  448-50     Citation Subset:  AIM; IM    
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MeSH Terms
Dihydroergotamine / administration & dosage
Heparin / administration & dosage
Leg / blood supply
Middle Aged
Physical Therapy Modalities
Postoperative Care
Postoperative Complications / prevention & control
Preoperative Care
Thrombophlebitis / diagnosis,  prevention & control*
Reg. No./Substance:
511-12-6/Dihydroergotamine; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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