Document Detail

Mechanical ventilation strategies for lung protection.
MedLine Citation:
PMID:  16088734     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A large body of animal literature has shown that lungs stretched beyond their normal maximum are likely to be injured and release inflammatory cytokines into the systemic circulation. Moreover, this injury seems to be compounded if alveolar collapse also occurs. This has give rise to the notion that adequate positive end expiratory pressure (PEEP) to prevent derecruitment coupled with a tidal volume-PEEP combination that limits maximal distention to below the normal maximum is the ideal way to provide positive pressure ventilatory support. Some have argued that static pressure-volume plots to describe upper and lower inflection points are particularly important in implementing this approach. Supporting this concept is the recently completed NIH trial showing improved survival in acute respiratory distress syndrome (ARDS) when a small tidal volume strategy was used.
N R MacIntyre
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in respiratory and critical care medicine     Volume:  21     ISSN:  1069-3424     ISO Abbreviation:  Semin Respir Crit Care Med     Publication Date:  2000  
Date Detail:
Created Date:  2005-08-09     Completed Date:  2005-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431858     Medline TA:  Semin Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  -    
Duke University Medical Center, Durham, North Carolina 27710, USA.
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