Document Detail

Mechanical ventilation mode (volume × pressure) does not change the variables obtained by indirect calorimetry in critically ill patients.
MedLine Citation:
PMID:  20080021     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the study was to analyze the difference between the results obtained by indirect calorimetry (IC) using volume-controlled and pressure-controlled mechanical ventilation in 2 different ventilators and to characterize the variables achieved by IC after well-defined changes in minute volume (Vm).
MATERIALS AND METHODS: Prospective study of 20 critically ill patients under volume-controlled (n = 15) or pressure-controlled (n = 5) mechanical ventilation. Three IC measurements of 45 minutes each were taken; values of oxygen consumption (Vo(2)), carbon dioxide production (Vco(2)), Vm, resting energy expenditure (REE), and respiratory quotient (RQ) were obtained. For the last measurement, Vm was set at 20% above the baseline.
RESULTS: There were no differences between the results obtained by IC during volume-controlled and pressure-controlled mechanical ventilation. The most relevant changes in the variables obtained by IC before and after intervention in Vm were a significant increase in Vco(2) (from 165 to 177 mL·min(-1); P < .01), a decrease in Paco(2) (from 38.49 to 28.46 mm Hg; P < .01), and a rise in pH (from 7.41 to 7.49; P < .01). There were no alterations in Vo(2), REE, or RQ.
CONCLUSIONS: Ventilators and ventilation modes do not influence the IC measurements. The observed changes have no clinical effects and are reversible, provided that increased Vm is maintained for no longer than 45 minutes.
Franciele C Meireles Clapis; Maria Auxiliadora-Martins; Camila Cremonezi Japur; Olindo Assis Martins-Filho; Paulo Roberto Barbosa Evora; Anibal Basile-Filho
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-15
Journal Detail:
Title:  Journal of critical care     Volume:  25     ISSN:  1557-8615     ISO Abbreviation:  J Crit Care     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  659.e9-16     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil.
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MeSH Terms
Aged, 80 and over
Calorimetry, Indirect / statistics & numerical data*
Carbon Dioxide / analysis
Critical Care*
Critical Illness
Energy Metabolism / physiology
Middle Aged
Oxygen Consumption / physiology
Prospective Studies
Reproducibility of Results
Respiration, Artificial / instrumentation*,  methods*
Rest / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide

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