| Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury. | |
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MedLine Citation:
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PMID: 16837499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to determine the effects of mechanical ventilation on alveolar fibrin turnover in lipopolysaccharide (LPS)-induced lung injury. In a randomised controlled trial, Sprague-Dawley rats (n = 61) were allocated to three ventilation groups after intratracheal LPS (Salmonella enteritidis) instillations. Group I animals were subjected to 16 cmH(2)O positive inspiratory pressure (PIP) and 5 cmH(2)O positive end-expiratory pressure (PEEP); group II animals to 26 cmH(2)O PIP and 5 cmH(2)O PEEP; and group III animals to 35 cmH(2)O PIP and 5 cmH(2)O PEEP. Control rats (not mechanically ventilated) received LPS. Healthy rats served as a reference group. Levels of thrombin-antithrombin complex (TATc), D-dimer, plasminogen activator inhibitor (PAI) activity and PAI-1 antigen in bronchoalveolar lavage fluid were measured. LPS-induced lung injury increased TATc, D-dimer and PAI activity and PAI-1 antigen levels versus healthy animals. High pressure-amplitude ventilation increased TATc concentrations. D-dimer concentrations were not significantly raised. Instead, PAI activity increased with the amplitude of the pressure, from 0.7 U.mL(-1) in group I to 3.4 U.mL(-1) in group II and 5.0 U.mL(-1) in group III. There was no change in PAI-1 antigen levels. In conclusion, mechanical ventilation creates an alveolar/pulmonary anti-fibrinolytic milieu in endotoxin-induced lung injury which, at least in part, might be due to an increase in plasminogen activator inhibitor activity. |
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Authors:
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P Dahlem; A P Bos; J J Haitsma; M J Schultz; E K Wolthuis; J C M Meijers; B Lachmann |
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Publication Detail:
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Type: Journal Article Date: 2006-07-12 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 28 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-31 Completed Date: 2007-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 992-8 Citation Subset: IM |
Affiliation:
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Dept of Anaesthesiology, Erasmus MC-Faculty Rotterdam, Rotterdam, Amsterdam. PDahlem@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / chemistry Disease Models, Animal Fibrinolysis / physiology* Lipopolysaccharides / adverse effects* Male Pulmonary Alveoli / injuries*, metabolism, microbiology* Rats Rats, Sprague-Dawley Respiration, Artificial / adverse effects* Respiratory Distress Syndrome, Adult / physiopathology Salmonella enteritidis / pathogenicity* |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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