Document Detail

Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury.
MedLine Citation:
PMID:  16837499     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to determine the effects of mechanical ventilation on alveolar fibrin turnover in lipopolysaccharide (LPS)-induced lung injury. In a randomised controlled trial, Sprague-Dawley rats (n = 61) were allocated to three ventilation groups after intratracheal LPS (Salmonella enteritidis) instillations. Group I animals were subjected to 16 cmH(2)O positive inspiratory pressure (PIP) and 5 cmH(2)O positive end-expiratory pressure (PEEP); group II animals to 26 cmH(2)O PIP and 5 cmH(2)O PEEP; and group III animals to 35 cmH(2)O PIP and 5 cmH(2)O PEEP. Control rats (not mechanically ventilated) received LPS. Healthy rats served as a reference group. Levels of thrombin-antithrombin complex (TATc), D-dimer, plasminogen activator inhibitor (PAI) activity and PAI-1 antigen in bronchoalveolar lavage fluid were measured. LPS-induced lung injury increased TATc, D-dimer and PAI activity and PAI-1 antigen levels versus healthy animals. High pressure-amplitude ventilation increased TATc concentrations. D-dimer concentrations were not significantly raised. Instead, PAI activity increased with the amplitude of the pressure, from 0.7 U.mL(-1) in group I to 3.4 U.mL(-1) in group II and 5.0 U.mL(-1) in group III. There was no change in PAI-1 antigen levels. In conclusion, mechanical ventilation creates an alveolar/pulmonary anti-fibrinolytic milieu in endotoxin-induced lung injury which, at least in part, might be due to an increase in plasminogen activator inhibitor activity.
P Dahlem; A P Bos; J J Haitsma; M J Schultz; E K Wolthuis; J C M Meijers; B Lachmann
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Publication Detail:
Type:  Journal Article     Date:  2006-07-12
Journal Detail:
Title:  The European respiratory journal     Volume:  28     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2007-02-06     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  992-8     Citation Subset:  IM    
Dept of Anaesthesiology, Erasmus MC-Faculty Rotterdam, Rotterdam, Amsterdam.
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MeSH Terms
Bronchoalveolar Lavage Fluid / chemistry
Disease Models, Animal
Fibrinolysis / physiology*
Lipopolysaccharides / adverse effects*
Pulmonary Alveoli / injuries*,  metabolism,  microbiology*
Rats, Sprague-Dawley
Respiration, Artificial / adverse effects*
Respiratory Distress Syndrome, Adult / physiopathology
Salmonella enteritidis / pathogenicity*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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