Document Detail


Mechanical-tactile stimulation (MTS) during neonatal stress prevents hyperinsulinemia despite stress-induced adiposity in weanling rat pups.
MedLine Citation:
PMID:  21211914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stress in early life negatively influences growth quality through perturbations in body composition including increased fat mass. At term (40 weeks) preterm infants have greater fat mass and abdominal visceral adipose tissue than term-born infants. Mechanical-tactile stimulation (MTS) attenuates the stress response in preterm infants and rodents. We tested the hypothesis that MTS, administered during an established model of neonatal stress, would decrease stress-driven adiposity and prevent associated metabolic imbalances in rat pups. Pups received one of three treatments from postnatal days 5 to P9: Neonatal Stress (Stress; n=20) = painful stimulus and hypoxic/hyperoxic challenge during 60 min of maternal separation; MTS (n=20) = neonatal stress+10 min of MTS; or Control (n=20). Body weight, DXA whole body fat mass (g), MRI subcutaneous and visceral adipose tissue, and fasting adiponectin, leptin, glucose, insulin, and corticosterone were measured at weaning (P21). Stress and MTS weight gain (g/d) were accelerated following neonatal stress with greater fat mass, abdominal subcutaneous adipose tissue, serum adiponectin, leptin, and fasting glucose at weaning (P21). Male Stress and MTS pups had greater visceral adipose tissue depot. Male and female Stress pups were hyperinsulinemic. In summary, neonatal stress compromised body composition by increasing fat mass and abdominal subcutaneous adipose tissue depot, and in males, visceral adipose tissue depot. Importantly, MTS prevented hyperinsulinemia despite of stress-induced adiposity. We conclude that MTS during neonatal stress has the potential to minimize metabolic consequences associated with stress-driven perturbations in fat mass and abdominal adipose depots.
Authors:
Laurie J Moyer-Mileur; Shannon Haley; Kristina Gulliver; Anne Thomson; Hillarie Slater; Brett Barrett; Lisa A Joss-Moore; Christopher Callaway; Robert A McKnight; Barry Moore; Robert H Lane
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Publication Detail:
Type:  Journal Article     Date:  2011-01-06
Journal Detail:
Title:  Early human development     Volume:  87     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-25     Completed Date:  2011-06-29     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Center for Pediatric Nutrition Research, University of Utah, Salt Lake City, UT 84108, USA. laurie.moyer-mileur@hsc.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adiponectin / blood
Animals
Animals, Newborn
Blood Glucose / analysis
Body Composition / physiology
Body Weight / physiology
Corticosterone / blood
Female
Hyperinsulinism / metabolism*,  prevention & control
Intra-Abdominal Fat / metabolism*
Leptin / blood
Magnetic Resonance Imaging
Male
Rats
Rats, Sprague-Dawley
Stress, Physiological / physiology*
Touch / physiology*
Grant Support
ID/Acronym/Agency:
F32 AT005568-01/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Blood Glucose; 0/Leptin; 50-22-6/Corticosterone
Comments/Corrections

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