| Mechanical stress and morphogenetic endochondral ossification of the sternum. | |
| | |
MedLine Citation:
|
PMID: 3403589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The possible role of mechanical stress in determining the patterns of endochondral ossification in skeletal anlages was explored using stress-analysis computer models of developing human sterna. It has been hypothesized previously that the normal sequence of proliferation, maturation, degeneration, and ossification of cartilage is accelerated in regions of high cyclic octahedral shear stress and inhibited in regions of intermittent compressive-hydrostatic (dilatational) stress. This hypothesis was investigated using two-dimensional, all-cartilage, plane-stress finite-element models of the three basic shapes of human sterna that were identified by Ashley. A mathematical criterion, which combined the opposing influences of the shear and dilatational stresses into a single net stimulus for ossification, was used successfully to simulate the three basic patterns of sternal endochondral ossification that were previously documented. Our findings support the view that mechanical forces may strongly influence skeletal morphogenesis, growth, and development, beginning at a very early stage. |
| | |
Authors:
|
M Wong; D R Carter |
Related Documents
:
|
19946259 - Decreased [99mtc]sestamibi uptake with dobutamine versus dipyridamole stress. 20937379 - Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geom... 8447259 - Prognostic usefulness of positive or negative exercise stress echocardiography for pred... 19307099 - Comparative diagnostic accuracy of multiplane and multislice three-dimensional dobutami... 10147729 - Echocardiography in coronary artery disease. 14969609 - Comparison of functional recovery of mildly hypokinetic versus severely dysfunctional l... 7140399 - Collateral circulation in patients with unstable angina. 1986169 - Factors predictive of results of direct ablative operations for drug-refractory ventric... 11684919 - Clinical manifestations of acute myocardial infarction in older patients. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The Journal of bone and joint surgery. American volume Volume: 70 ISSN: 0021-9355 ISO Abbreviation: J Bone Joint Surg Am Publication Date: 1988 Aug |
Date Detail:
|
Created Date: 1988-09-22 Completed Date: 1988-09-22 Revised Date: 2010-10-25 |
Medline Journal Info:
|
Nlm Unique ID: 0014030 Medline TA: J Bone Joint Surg Am Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 992-1000 Citation Subset: AIM; IM; S |
Affiliation:
|
Rehabilitation Research and Development Center, Veterans Administration Medical Center, Palo Alto, California. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Computer Simulation* Humans Hydrostatic Pressure Morphogenesis Osteogenesis* Sternum / embryology*, growth & development Stress, Mechanical* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proximal tibial osteotomy in patients who are fifty years old or less. A long-term follow-up study.
Next Document: Peripheral nerve repair in humans using muscle autografts. A new technique.