Document Detail


Mechanical stress and morphogenetic endochondral ossification of the sternum.
MedLine Citation:
PMID:  3403589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The possible role of mechanical stress in determining the patterns of endochondral ossification in skeletal anlages was explored using stress-analysis computer models of developing human sterna. It has been hypothesized previously that the normal sequence of proliferation, maturation, degeneration, and ossification of cartilage is accelerated in regions of high cyclic octahedral shear stress and inhibited in regions of intermittent compressive-hydrostatic (dilatational) stress. This hypothesis was investigated using two-dimensional, all-cartilage, plane-stress finite-element models of the three basic shapes of human sterna that were identified by Ashley. A mathematical criterion, which combined the opposing influences of the shear and dilatational stresses into a single net stimulus for ossification, was used successfully to simulate the three basic patterns of sternal endochondral ossification that were previously documented. Our findings support the view that mechanical forces may strongly influence skeletal morphogenesis, growth, and development, beginning at a very early stage.
Authors:
M Wong; D R Carter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of bone and joint surgery. American volume     Volume:  70     ISSN:  0021-9355     ISO Abbreviation:  J Bone Joint Surg Am     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-22     Completed Date:  1988-09-22     Revised Date:  2010-10-25    
Medline Journal Info:
Nlm Unique ID:  0014030     Medline TA:  J Bone Joint Surg Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  992-1000     Citation Subset:  AIM; IM; S    
Affiliation:
Rehabilitation Research and Development Center, Veterans Administration Medical Center, Palo Alto, California.
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MeSH Terms
Descriptor/Qualifier:
Computer Simulation*
Humans
Hydrostatic Pressure
Morphogenesis
Osteogenesis*
Sternum / embryology*,  growth & development
Stress, Mechanical*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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