| Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. | |
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MedLine Citation:
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PMID: 21444750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The notion that cell shape and spreading can regulate cell proliferation has evolved over several years, but only recently has this been linked to forces from within and upon the cell. This emerging area of mechanical signaling is proving to be wide-spread and important for all cell types. The microenvironment that surrounds cells provides a complex spectrum of different, simultaneously active, biochemical, structural and mechanical stimuli. In this milieu, cells probe the stiffness of their microenvironment by pulling on the extracellular matrix (ECM) and/or adjacent cells. This process is dependent on transcellular cell-ECM or cell-cell adhesions, as well as cell contractility mediated by Rho GTPases, to provide a functional linkage through which forces are transmitted through the cytoskeleton by intracellular force-generating proteins. This Commentary covers recent advances in the underlying mechanisms that control cell proliferation by mechanical signaling, with an emphasis on the role of 3D microenvironments and in vivo extracellular matrices. Moreover, as there is much recent interest in the tumor-stromal interaction, we will pay particular attention to exciting new data describing the role of mechanical signaling in the progression of breast cancer. |
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Authors:
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Paolo P Provenzano; Patricia J Keely |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of cell science Volume: 124 ISSN: 1477-9137 ISO Abbreviation: J. Cell. Sci. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-29 Completed Date: 2011-09-02 Revised Date: 2012-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: England |
Other Details:
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Languages: eng Pagination: 1195-205 Citation Subset: IM |
Affiliation:
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Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. ppproven@fhcrc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation* Cytoskeleton / enzymology, genetics, metabolism* Focal Adhesions / enzymology*, metabolism* Humans Mechanotransduction, Cellular* Neoplasms / enzymology, genetics, metabolism* Signal Transduction rho GTP-Binding Proteins / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA114462/CA/NCI NIH HHS; CA142833/CA/NCI NIH HHS; CA152249/CA/NCI NIH HHS; R21 CA152249-02/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.6.5.2/rho GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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