Document Detail


Mechanical properties of porcine and human arteries: implications for coronary anastomotic connectors.
MedLine Citation:
PMID:  12842513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To determine whether the pig is an appropriate experimental animal for studies on distal anastomotic connectors in coronary artery bypass surgery, the mechanical properties of young porcine and old human coronary and internal mammary arteries were compared within and beyond the physiologic range of strains. METHODS: Coronary arteries from 6 humans and 8 pigs were studied as well as internal mammary arteries of 3 humans and 6 pigs (human, aged 61 to 85 years; pig, 78.7 +/- 5.8 kg [mean +/- SD]). Pressure-diameter, pressure-axial force, circumferential and axial stress-strain relations, and dimensions were measured. RESULTS: The dimensions of the porcine and human coronary and internal mammary artery were generally similar but wall thickness was smaller in the porcine internal mammary artery (0.35 +/- 0.07 mm versus 0.71 +/- 0.06 mm, respectively, p = 0.002). The porcine internal mammary artery wall was less elastic than the coronary artery wall, whereas in humans both arteries displayed similar elasticity. Overall the porcine arteries were far more elastic in both circumferential and axial direction compared with the human arteries. Consequently the porcine arteries could be safely stretched by 60% to 70% compared with about 20% for the human arteries before reaching their maximum circumferential strain. CONCLUSIONS: The three times greater elasticity of porcine compared with human coronary and internal mammary artery walls may result in underestimation of wall stress and the risk of wall injury when coronary connectors that involve overstretching of the wall are evaluated in the pig.
Authors:
Carolien J van Andel; Peter V Pistecky; Cornelius Borst
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  76     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-10-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-64; discussion 64-5     Citation Subset:  AIM; IM    
Affiliation:
Experimental Cardiology Laboratory, Heart Lung Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Analysis of Variance
Animals
Cadaver
Compressive Strength*
Coronary Vessels / physiology*,  surgery
Culture Techniques
Humans
Internal Mammary-Coronary Artery Anastomosis*
Mammary Arteries / physiology*,  surgery
Middle Aged
Probability
Species Specificity
Stress, Mechanical
Swine
Tensile Strength

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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