Document Detail


Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery.
MedLine Citation:
PMID:  19111338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously reported the initial clinical feasibility with our small diameter tissue engineered blood vessel (TEBV). Here we present in vitro results of the mechanical properties of the TEBVs of the first 25 patients enrolled in an arterio-venous (A-V) shunt safety trial, and compare these properties with those of risk-matched human vein and artery. TEBV average burst pressures (3490+/-892 mmHg, n=230) were higher than native saphenous vein (SV) (1599+/-877 mmHg, n=7), and not significantly different from native internal mammary artery (IMA) (3196+/-1264 mmHg, n=16). Suture retention strength for the TEBVs (152+/-50 gmf) was also not significantly different than IMA (138+/-50 gmf). Compliance for the TEBVs prior to implantation (3.4+/-1.6%/100 mmHg) was lower than IMA (11.5+/-3.9%/100 mmHg). By 6 months post-implant, the TEBV compliance (8.8+/-4.2%/100 mmHg, n=5) had increased to values comparable to IMA, and showed no evidence of dilation or aneurysm formation. With clinical time points beyond 21 months as an A-V shunt without intervention, the mechanical tests and subsequent lot release criteria reported here would seem appropriate minimum standards for clinical use of tissue engineered vessels.
Authors:
Gerhardt Konig; Todd N McAllister; Nathalie Dusserre; Sergio A Garrido; Corey Iyican; Alicia Marini; Alex Fiorillo; Hernan Avila; Wojciech Wystrychowski; Krzysztof Zagalski; Marcin Maruszewski; Alyce Linthurst Jones; Lech Cierpka; Luis M de la Fuente; Nicolas L'Heureux
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural     Date:  2008-12-25
Journal Detail:
Title:  Biomaterials     Volume:  30     ISSN:  1878-5905     ISO Abbreviation:  Biomaterials     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-03-27     Revised Date:  2010-09-23    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  1542-50     Citation Subset:  IM    
Affiliation:
Cytograft Tissue Engineering, 3 Hamilton Landing, Novato, CA 94949, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biomechanics
Blood Vessels / cytology,  physiology*
Demography
Female
Humans
Male
Mammary Arteries / physiology*
Middle Aged
Pressure
Saphenous Vein / physiology*
Tissue Donors
Tissue Engineering*
Grant Support
ID/Acronym/Agency:
5R44 HL 64462-6/HL/NHLBI NIH HHS; R44 HL064462-06/HL/NHLBI NIH HHS
Comments/Corrections

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