| Mechanical properties of cells and ageing. | |
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MedLine Citation:
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PMID: 19897057 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Mechanical properties are fundamental properties of the cells and tissues of living organisms. The mechanical properties of a single cell as a biocomposite are determined by the interdependent combination of cellular components mechanical properties. Quantitative estimate of the cell mechanical properties depends on a cell state, method of measurement, and used theoretical model. Predominant tendency for the majority of cells with ageing is an increase of cell stiffness and a decrease of cell ability to undergo reversible large deformations. The mechanical signal transduction in old cells becomes less effective than that in young cells, and with ageing, the cells lose the ability of the rapid functional rearrangements of cellular skeleton. The article reviews the theoretical and experimental facts touching the age-related changes of the mechanical properties of cellular components and cells in the certain systems of an organism (the blood, the vascular system, the musculoskeletal system, the lens, and the epithelium). In fact, the cell mechanical parameters (including elastic modulii) can be useful as specific markers of cell ageing. |
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Authors:
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Maria N Starodubtseva |
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Publication Detail:
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Type: Journal Article Date: 2009-11-06 |
Journal Detail:
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Title: Ageing research reviews Volume: 10 ISSN: 1872-9649 ISO Abbreviation: Ageing Res. Rev. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128963 Medline TA: Ageing Res Rev Country: England |
Other Details:
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Languages: eng Pagination: 16-25 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Biological and Medical Physics, Gomel State Medical University, Lange str., 5, 246000 Gomel, Belarus. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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