| Mechanical profiling of intervertebral discs. | |
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MedLine Citation:
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PMID: 19345361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite recent advances in imaging diagnostic technology and additional treatment options our ability to prevent or inhibit discogenic back pain has not drastically improved. The challenge of linking early degenerative patterns to dysfunction and pain remains. Using a novel material testing device designated the tissue diagnostic instrument (TDI) we measured the local stiffness and strain energy absorption in the radial direction of 13 intact intervertebral discs; effectively generating a mechanical profile of each disc. Prior to measuring mechanical properties, an MR image was taken of each spine segment and the discs were radiologically scored according to the Pfirrmann scale. After testing, a sagittal portion of each L1-L2 disc was excised from each of four spines for histology. No significant correlations were found between Pfirrmann grade and mechanical data. However, polarized light microscopy images of disc sections indicated correlations between local tissue modulus measured with the TDI and the clarity and density of lamellar striations. |
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Authors:
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David S Schultz; Azucena G Rodriguez; Paul K Hansma; Jeffrey C Lotz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-04-03 |
Journal Detail:
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Title: Journal of biomechanics Volume: 42 ISSN: 1873-2380 ISO Abbreviation: J Biomech Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-18 Completed Date: 2009-09-01 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: United States |
Other Details:
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Languages: eng Pagination: 1154-7 Citation Subset: IM |
Affiliation:
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UCSF Department of Orthopaedic Surgery, UC Hall U, San Francisco, CA 94143-0565, USA. dschultz@newton.berkeley.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biomechanics Humans Intervertebral Disc / physiopathology*, radiography Lumbar Vertebrae / physiopathology, radiography Magnetic Resonance Imaging Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR049770/AR/NIAMS NIH HHS; R01 AR049770-04/AR/NIAMS NIH HHS; R01 AR049770-05/AR/NIAMS NIH HHS; R01 GM065354-01/GM/NIGMS NIH HHS; R01AR049770/AR/NIAMS NIH HHS; R01GM65354/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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