Document Detail

Mechanical overload of a single compartment induces early degenerative changes in the rabbit knee: a preliminary study.
MedLine Citation:
PMID:  2069926     Owner:  NLM     Status:  MEDLINE    
The purpose of this experiment was to determine whether mechanical overload of a single compartment of the knee in rabbits via proximal tibial osteotomy could produce early changes consistent with degenerative arthritis. Ten New Zealand white female rabbits were allocated into two groups. Group 1 (five animals) underwent a right 20 degrees valgus proximal tibial osteotomy to overload the lateral compartment of the knee. Group 2 (five animals) underwent a tibial osteotomy without malalignment (sham controls). The osteotomies were stabilized with a mini AO/ASIF plate and screws, allowing early mobilization. The left leg in each animal was left intact and served as a control. Animals were sacrificed after 3 months. Histological grading of the cartilage was performed according to Mankin et al. The mean histological gradings for the right minus the left knee were the same for the lateral and medial compartments in the 0 degrees sham osteotomy group. However, the mean histological grading of the "overloaded" lateral compartment was 2.4 times greater than the medial compartment in the 20 degrees valgus osteotomy group. These findings suggest that histological evidence of degenerative changes can be surgically induced in the rabbit knee by creating a biomechanical overload of one compartment.
S B Goodman; J Lee; R L Smith; J C Csongradi; V L Fornasier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  4     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-22     Completed Date:  1991-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-70     Citation Subset:  IM    
Division of Orthopaedic Surgery, Stanford University Medical Center, CA 94305.
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MeSH Terms
Cartilage, Articular / pathology
Disease Models, Animal
Knee Joint / pathology
Osteoarthritis / etiology*
Stress, Mechanical
Tibia / surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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