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Mechanical instabilities of biological tubes.
MedLine Citation:
PMID:  23031132     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We study theoretically the morphologies of biological tubes affected by various pathologies. When epithelial cells grow, the negative tension produced by their division provokes a buckling instability. Several shapes are investigated: varicose, dilated, sinuous, or sausagelike. They are all found in pathologies of tracheal, renal tubes, or arteries. The final shape depends crucially on the mechanical parameters of the tissues: Young's modulus, wall-to-lumen ratio, homeostatic pressure. We argue that since tissues must be in quasistatic mechanical equilibrium, abnormal shapes convey information as to what causes the pathology. We calculate a phase diagram of tubular instabilities which could be a helpful guide for investigating the underlying genetic regulation.
Authors:
Edouard Hannezo; Jacques Prost; Jean-François Joanny
Publication Detail:
Type:  Journal Article     Date:  2012-07-03
Journal Detail:
Title:  Physical review letters     Volume:  109     ISSN:  1079-7114     ISO Abbreviation:  Phys. Rev. Lett.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401141     Medline TA:  Phys Rev Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  018101     Citation Subset:  IM    
Affiliation:
Physicochimie Curie (Institut Curie/CNRS-UMR168/UPMC), Institut Curie, Centre de Recherche, 26 rue d'Ulm F-75248 Paris Cedex 05, France.
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