| Mechanical instabilities of biological tubes. | |
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MedLine Citation:
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PMID: 23031132 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We study theoretically the morphologies of biological tubes affected by various pathologies. When epithelial cells grow, the negative tension produced by their division provokes a buckling instability. Several shapes are investigated: varicose, dilated, sinuous, or sausagelike. They are all found in pathologies of tracheal, renal tubes, or arteries. The final shape depends crucially on the mechanical parameters of the tissues: Young's modulus, wall-to-lumen ratio, homeostatic pressure. We argue that since tissues must be in quasistatic mechanical equilibrium, abnormal shapes convey information as to what causes the pathology. We calculate a phase diagram of tubular instabilities which could be a helpful guide for investigating the underlying genetic regulation. |
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Authors:
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Edouard Hannezo; Jacques Prost; Jean-François Joanny |
Publication Detail:
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Type: Journal Article Date: 2012-07-03 |
Journal Detail:
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Title: Physical review letters Volume: 109 ISSN: 1079-7114 ISO Abbreviation: Phys. Rev. Lett. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-10-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401141 Medline TA: Phys Rev Lett Country: United States |
Other Details:
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Languages: eng Pagination: 018101 Citation Subset: IM |
Affiliation:
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Physicochimie Curie (Institut Curie/CNRS-UMR168/UPMC), Institut Curie, Centre de Recherche, 26 rue d'Ulm F-75248 Paris Cedex 05, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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