Document Detail

Mechanical heart valve performance in a pulsatile pediatric ventricular assist device.
MedLine Citation:
PMID:  17237654     Owner:  NLM     Status:  MEDLINE    
A pulsatile pediatric ventricular assist device with a dynamic stroke volume of 12 ml is currently under development at the Pennsylvania State University. A monoleaflet valve (Björk-Shiley Monostrut) and a bileaflet valve (CPHV, CarboMedics Prosthetic Heart Valve) were examined in this study. A high-speed video and data acquisition system was used to simultaneously record video images, pressure waveforms, and flow waveforms for an array of in vitro test conditions that varied heart rate and systolic duration. The CPHV in both the horizontal and vertical orientations have larger regurgitant volumes than the Monostrut valves at all operating conditions in both the inlet and outlet positions. However, the CPHV has higher stroke volumes and cardiac outputs than the Monostrut valve at higher heart rates and longer systolic durations. In addition, the hydrodynamic performance of the Monostrut valve is more sensitive to changes in operating conditions for the pulsatile pediatric ventricular assist device than the CPHV in both orientations. Additional testing is under way to identify the optimal operating conditions for each type of valve.
Conrad M Zapanta; LeAnn M Dourte; Bradley J Doxtater; Branka Lukic; William J Weiss
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  53     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-02-01     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-96     Citation Subset:  IM    
Division of Artificial Organs, Department of Surgery, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
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MeSH Terms
Heart Rate
Heart Valve Prosthesis*
Heart-Assist Devices*
Pulsatile Flow
Stroke Volume
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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