Document Detail


Mechanical guidance of cell migration: lessons from chemotaxis.
MedLine Citation:
PMID:  23726023     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
For an organism to develop, for a wound to heal, or for a tumor to invade, cells must be able to migrate following directional cues. It is widely accepted that directed cell migration is enabled by cellular sensing of local gradients in the concentration of chemical factors. The main molecular players involved in this mode of cellular guidance-chemotaxis-have been identified and the combination of modeling and experimental approaches is progressively unveiling a clear picture of the underlying mechanisms. Evidence obtained over the past decade has shown that cells can also be guided by mechanical stimuli such as physical forces or gradients in extracellular matrix stiffness. Mechanical guidance, which we refer here globally as mechanotaxis, is also thought to drive processes in development, cancer, and wound healing, but experimental evidence is scattered and mechanisms remain largely unknown. Here we use the better understood process of chemotaxis as a reference to define the building blocks that are required for cell guidance, and then discuss how these building blocks might be organized in mechanotaxis. We show that both chemotaxis and mechanotaxis involve an exquisite interplay between physical and chemical mechanisms to sense gradients, establish polarization, and drive directed migration.
Authors:
Pere Roca-Cusachs; Raimon Sunyer; Xavier Trepat
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-28
Journal Detail:
Title:  Current opinion in cell biology     Volume:  -     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Ltd.
Affiliation:
Institute for Bioengineering of Catalonia, Barcelona, Spain; University of Barcelona, Barcelona, Spain. Electronic address: rocacusachs@ub.edu.
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