Document Detail


Mechanical and chemical characteristics of an autologous glue.
MedLine Citation:
PMID:  18080308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study evaluates the mechanical and chemical characteristics of autologous surgical glue made by mixing ultrafiltered plasma with glutaraldehyde (GTA). Human albumin 200 g/L mixed with different concentrations of GTA (25, 50, 75, or 100 g/L) was used as a single protein set-up for testing tensile strength, elasticity, and rate of crosslinking. Subsequently, ultrafiltered canine or human plasma to obtain autologous glue replaced human albumin. BioGlue, a surgical glue, and Tissucol Duo, a fibrin sealant, were used as controls. Tensile strength of human albumin 200 g/L mixed with 75 g/L GTA is 825 +/- 109 N versus 672 +/- 167 N for BioGlue. Ultrafiltered canine plasma showed a maximum tensile strength of 634 +/- 137 N when mixed with GTA 75 g/L. For human plasma, the maximum tensile strength of 436 +/- 69 N was reached after mixing with GTA 25 g/L. Autologous glue had a higher elasticity of 144 +/- 66 N versus 322 +/- 104 N for BioGlue at maximum load. Autologous glues for vascular repair can be easily prepared out of the patient's plasma. The optimal characteristics, compared to BioGlue, are obtained for ultrafiltered canine and human plasma by mixing with a GTA concentration of 50-75 g/L and 25-50 g/L, respectively. The autologous glue will exert less tensile strength than BioGlue but has a better compliance. In case where no plasma can obtained from the patient, mixing human albumin 200 g/L with GTA 75 g/L can be an alternative to BioGlue.
Authors:
Filip De Somer; Joris Delanghe; Pamela Somers; Maarten Debrouwere; Guido Van Nooten
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  86     ISSN:  1552-4965     ISO Abbreviation:  -     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1106-12     Citation Subset:  IM    
Affiliation:
Heart Centre 5IE-K12, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium. Filip.DeSomer@UGent.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Cell Death / drug effects
Chickens
Cross-Linking Reagents / pharmacology
Dogs
Elasticity / drug effects
Fibroblasts / cytology,  drug effects
Glutaral / pharmacology
Humans
Materials Testing*
Proteins / chemistry*,  pharmacology
Tensile Strength / drug effects
Chemical
Reg. No./Substance:
0/Bio-glue; 0/Cross-Linking Reagents; 0/Proteins; 111-30-8/Glutaral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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