Document Detail


Mechanical characteristics of the canine thoracic duct: what are the driving forces of the lymph flow?
MedLine Citation:
PMID:  10818637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study is designed to better understand the mode of lymph transport, particularly through the extrinsic pumping by external compression of the lymph vessel. The pressure-diameter relationship of lymphatic segments isolated from the canine thoracic duct was examined using a laser optical micrometer measurement system. Results revealed that the thoracic duct displayed a high extensibility or compliance in the physiological pressure range, yet became progressively less so with increasing internal pressure. The calculated incremental circumferential modulus of the thoracic duct under physiological pressure (range of 2 to 6 cm H2O) showed values ranging from 1.2 x 10(4) to 3.61 x 10(5) dyn/cm2. At a pressure of 35 cm H2O, the modulus reached a limiting value of approximately 6.0 x 10(6) dyn/cm2. In the physiological pressure range, the relative wall thickness (h/R0) of the canine thoracic duct was approximately 3.5%, which was much lower than that reported for canine arterial segments and similar in value to that of the canine jugular vein. In conclusion, the pressure-diameter curve of the canine thoracic duct was shown to resemble that of venous vessels. However, the circumferential elastic modulus of the thoracic duct wall was lower than the moduli of veins, proving that lymphatics are more compliant than veins. This suggests lymph flow in the thoracic duct may be better promoted by external compression of the lymphatic vessel.
Authors:
X Deng; G Marinov; Y Marois; R Guidoin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biorheology     Volume:  36     ISSN:  0006-355X     ISO Abbreviation:  Biorheology     Publication Date:  1999  
Date Detail:
Created Date:  2000-05-25     Completed Date:  2000-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372526     Medline TA:  Biorheology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  391-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, Laval University, Ste-Foy, PQ, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Elasticity
Lymph / physiology
Microscopy, Confocal
Rheology
Thoracic Duct / anatomy & histology,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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