| Mechanical buckling of artery under pulsatile pressure. | |
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MedLine Citation:
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PMID: 22356844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tortuosity that often occurs in carotid and other arteries has been shown to be associated with high blood pressure, atherosclerosis, and other diseases. However the mechanisms of tortuosity development are not clear. Our previous studies have suggested that arteries buckling could be a possible mechanism for the initiation of tortuous shape but artery buckling under pulsatile flow condition has not been fully studied. The objectives of this study were to determine the artery critical buckling pressure under pulsatile pressure both experimentally and theoretically, and to elucidate the relationship of critical pressures under pulsatile flow, steady flow, and static pressure. We first tested the buckling pressures of porcine carotid arteries under these loading conditions, and then proposed a nonlinear elastic artery model to examine the buckling pressures under pulsatile pressure conditions. Experimental results showed that under pulsatile pressure arteries buckled when the peak pressures were approximately equal to the critical buckling pressures under static pressure. This was also confirmed by model simulations at low pulse frequencies. Our results provide an effective tool to predict artery buckling pressure under pulsatile pressure. |
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Authors:
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Qin Liu; Hai-Chao Han |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-02-21 |
Journal Detail:
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Title: Journal of biomechanics Volume: 45 ISSN: 1873-2380 ISO Abbreviation: J Biomech Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-16 Completed Date: 2012-08-09 Revised Date: 2013-05-01 |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: United States |
Other Details:
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Languages: eng Pagination: 1192-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / physiology* Biomechanics Blood Pressure / physiology Carotid Arteries / physiology Computer Simulation Elasticity Humans Models, Cardiovascular* Nonlinear Dynamics Pulsatile Flow / physiology Sus scrofa |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL095852/HL/NHLBI NIH HHS; R01 HL095852-01A1/HL/NHLBI NIH HHS; R01 HL095852-02/HL/NHLBI NIH HHS; R01HL095852/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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