Document Detail


Mechanical blood-tissue interaction in contracting muscles: a model study.
MedLine Citation:
PMID:  9727337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A finite element (FE) model of blood perfused biological tissue has been developed. Blood perfusion is described by fluid flow through a series of 5 intercommunicating vascular compartments that are embedded in the tissue. Each compartment is characterized by a blood flow permeability tensor, blood volume fraction and vessel compliance. Local non-linear relationships between intra-extra vascular pressure difference and blood volume fraction, and between blood volume fraction and the permeability tensor, are included in the FE model. To test the implementation of these non-linear relations, FE results of blood perfusion in a piece of tissue that is subject to increased intramuscular pressure, are compared to results that are calculated with a lumped parameter (LP) model of blood perfusion. FE simulation of blood flow through a contracting rat calf muscle is performed. The FE model used in this simulation contains a transversely isotropic, non-linearly elastic description of deforming muscle tissue, in which local contraction stress is prescribed as a function of time. FE results of muscle tension, total arterial inflow and total venous outflow of the muscle during contraction, correspond to experimental results of an isometrically and tetanically contracting rat calf muscle.
Authors:
W J Vankan; J M Huyghe; C C van Donkelaar; M R Drost; J D Janssen; A Huson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomechanics     Volume:  31     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-11-17     Completed Date:  1998-11-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-9     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, Eindhoven University of Technology, Netherlands. josv@bw.unimaas.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / physiology
Blood Pressure / physiology
Blood Volume / physiology
Capillary Permeability / physiology
Computer Simulation
Elasticity
Finite Element Analysis*
Hemorheology
Isometric Contraction / physiology
Models, Biological
Muscle Contraction / physiology*
Muscle, Skeletal / blood supply*
Nonlinear Dynamics
Pressure
Rats
Regional Blood Flow / physiology
Stress, Mechanical
Vascular Capacitance / physiology
Veins / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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