Document Detail

Mechanical behavior of articular cartilage quantitative changes with enzymatic alteration of the proteoglycan fraction.
MedLine Citation:
PMID:  3038223     Owner:  NLM     Status:  MEDLINE    
The in-vitro viscoelastic mechanical response of normal rabbit articular cartilage is strongly dependent on the quantity and integrity of the proteoglycan fraction of the tissue matrix. Experimental results demonstrate that specific functional relationships exist between shear moduli, retardation time spectra, and proteoglycan content. Quantitative enzymolysis of the proteoglycan fraction of the tissue alters the form of these relationships in a fashion consistent with the altered physiochemical make-up of the tissue. The observed changes in mechanical behavior with controlled enzymolysis are similar to those associated with the early stages of osteoarthritis, rheumatoid arthritis, joint sepsis, and synovitis in animal models.
J R Parsons; J Black
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of the Hospital for Joint Diseases Orthopaedic Institute     Volume:  47     ISSN:  0883-9344     ISO Abbreviation:  Bull Hosp Jt Dis Orthop Inst     Publication Date:  1987  
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8207779     Medline TA:  Bull Hosp Jt Dis Orthop Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-30     Citation Subset:  IM    
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MeSH Terms
Cartilage, Articular / physiology*
Enzymes / physiology*
Glycosaminoglycans / physiology
Hexosamines / physiology
Hydroxyproline / physiology
Proteoglycans / physiology*
Reg. No./Substance:
0/Enzymes; 0/Glycosaminoglycans; 0/Hexosamines; 0/Proteoglycans; 51-35-4/Hydroxyproline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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