| Mechanical analysis of congestive heart failure caused by bundle branch block based on an electromechanical canine heart model. | |
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MedLine Citation:
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PMID: 19098354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asynchronous electrical activation, induced by bundle branch block (BBB), can cause reduced ventricular function. However, the effects of BBB on the mechanical function of heart are difficult to assess experimentally. Many heart models have been developed to investigate cardiac properties during BBB but have mainly focused on the electrophysiological properties. To date, the mechanical function of BBB has not been well investigated. Based on a three-dimensional electromechanical canine heart model, the mechanical properties of complete left and right bundle branch block (LBBB and RBBB) were simulated. The anatomical model as well as the fiber orientations of a dog heart was reconstructed from magnetic resonance imaging (MRI) and diffusion tensor MRI (DT-MRI). Using the solutions of reaction-diffusion equations and with a strategy of parallel computation, the asynchronous excitation propagation and intraventricular conduction in BBB was simulated. The mechanics of myocardial tissues were computed with time-, sarcomere length-dependent uniaxial active stress initiated at the time of depolarization. The quantification of mechanical intra- and interventricular asynchrony of BBB was then investigated using the finite-element method with an eight-node isoparametric element. The simulation results show that (1) there exists inter- and intraventricular systolic dyssynchrony during BBB; (2) RBBB may have more mechanical synchrony and better systolic function of the left ventricle (LV) than LBBB; (3) the ventricles always move toward the early-activated ventricle; and (4) the septum experiences higher stress than left and right ventricular free walls in BBB. The simulation results validate clinical and experimental recordings of heart deformation and provide regional quantitative estimates of ventricular wall strain and stress. The present work suggests that an electromechanical heart model, incorporating real geometry and fiber orientations, may be helpful for better understanding of the mechanical implications of congestive heart failure (CHF) caused by BBB. |
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Authors:
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Jianhong Dou; Ling Xia; Yu Zhang; Guofa Shou; Qing Wei; Feng Liu; Stuart Crozier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-19 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 54 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 353-71 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China. Guangzhou General Army Hospital, Guangzhou 510010, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics Biophysical Phenomena Bundle-Branch Block / complications*, physiopathology* Disease Models, Animal Dogs Electrophysiological Phenomena Heart Failure / etiology*, physiopathology* Imaging, Three-Dimensional Models, Anatomic Models, Cardiovascular* Movement / physiology Stroke Volume / physiology Systole / physiology |
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