Document Detail

Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats.
MedLine Citation:
PMID:  16942952     Owner:  NLM     Status:  MEDLINE    
PERSPECTIVE: To clarify the mechanisms of oral cancer pain, we examined the expression of calcitonin gene-related peptide, substance P, ATP receptor P2X(3), and capsaicin receptor TRPV1 in trigeminal ganglia. Characterizations of these molecular systems which mediate pain perception are important to develop novel clinical tools for promoting relief of oral cancer pain.
Kenjiro Nagamine; Noriyuki Ozaki; Masamichi Shinoda; Hideaki Asai; Hiroaki Nishiguchi; Kenji Mitsudo; Iwai Tohnai; Minoru Ueda; Yasuo Sugiura
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of pain : official journal of the American Pain Society     Volume:  7     ISSN:  1526-5900     ISO Abbreviation:  J Pain     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-31     Completed Date:  2006-11-03     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  100898657     Medline TA:  J Pain     Country:  United States    
Other Details:
Languages:  eng     Pagination:  659-70     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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MeSH Terms
Calcitonin Gene-Related Peptide / metabolism
Carcinoma, Squamous Cell / complications*,  physiopathology
Cell Line, Tumor
Disease Models, Animal
Gingiva / innervation,  pathology,  physiopathology*
Hot Temperature / adverse effects
Hyperalgesia / etiology*,  physiopathology
Mouth Mucosa / innervation,  pathology,  physiopathology
Mouth Neoplasms / complications*,  physiopathology
Neurons, Afferent / metabolism
Nociceptors / metabolism
Physical Stimulation / adverse effects
Rats, Inbred F344
Receptors, Purinergic P2 / metabolism
Receptors, Purinergic P2X3
Substance P / metabolism
TRPV Cation Channels / metabolism
Trigeminal Ganglion / cytology,  metabolism
Trigeminal Nerve / metabolism
Reg. No./Substance:
0/P2rx3 protein, rat; 0/Receptors, Purinergic P2; 0/Receptors, Purinergic P2X3; 0/TRPV Cation Channels; 0/Trpv1 protein, rat; 33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide

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