Document Detail


Mechanical and acid neutralizing properties and bacteria inhibition of amorphous calcium phosphate dental nanocomposite.
MedLine Citation:
PMID:  21504057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dental composites do not hinder bacteria colonization and plaque formation. Caries at the restoration margins is a frequent reason for replacement of existing restorations, which accounts for 50 to 70% of all restorations. The objectives of this study were to examine the filler level effect on nanocomposite containing nanoparticles of amorphous calcium phosphate (NACP) and investigate the load-bearing and acid-neutralizing properties and bacteria inhibition. NACP with 116-nm particle size were synthesized via a spray-drying technique and incorporated into a resin. Flexural strength of nanocomposite with 10 to 30% NACP fillers matched the strength of a commercial hybrid composite (p > 0.1). Nanocomposite with 40% NACP matched the strength of a microfill composite, which was 2-fold that of a resin-modified glass ionomer. Nanocomposite with 40% NACP neutralized a lactic acid solution of pH 4 by rapidly increasing the pH to 5.69 in 10 min. In contrast, the commercial controls had pH staying at near 4. Using Streptoccocus mutans, an agar disk-diffusion test showed no inhibition zone for commercial controls. In contrast, the inhibition zone was (2.5 ± 0.7) mm for nanocomposite with 40% NACP. Crystal violet staining showed that S. mutans coverage on nanocomposite was 1/4 that on commercial composite. In conclusion, novel calcium-phosphate nanocomposite matched the mechanical properties of commercial composite and rapidly neutralized lactic acid of pH 4. The nanocomposite appeared to moderately reduce the S. mutans growth, and further study is needed to obtain strong antimicrobial properties. The new nanocomposite may have potential to reduce secondary caries and restoration fracture, two main challenges facing tooth cavity restorations.
Authors:
Jennifer L Moreau; Limin Sun; Laurence C Chow; Hockin H K Xu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-18
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  98     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-02     Completed Date:  2011-09-22     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, Maryland 21201, USA.
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MeSH Terms
Descriptor/Qualifier:
Calcium Phosphates / chemistry*
Dental Cements / chemistry*
Hydrogen-Ion Concentration
Lactic Acid / chemistry
Nanocomposites / chemistry*
Particle Size
Streptococcus mutans / growth & development*
Grant Support
ID/Acronym/Agency:
R01 DE017974/DE/NIDCR NIH HHS; R01 DE11789/DE/NIDCR NIH HHS; R01 DE17974/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Phosphates; 0/Dental Cements; 50-21-5/Lactic Acid
Comments/Corrections

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