| Mechanical Versus Alcohol-assisted Epithelial Debridement During Photorefractive Keratectomy: A Confocal Microscopic Clinical Trial. | |
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MedLine Citation:
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PMID: 21877678 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE:To compare the effects of mechanical versus alcohol-assisted epithelial debridement on corneal cellular elements after photorefractive keratectomy (PRK) using confocal microscopy. METHODS:This randomized, clinical trial included 66 eyes from 33 patients with spherical equivalent refraction <-4.00 diopters (D). Mechanical versus alcohol-assisted epithelial debridement was performed during PRK. The right eye of each patient was randomly assigned to one group (mechanical group or alcohol-assisted group) and the fellow eye to the alternate group. Confocal examination was performed preoperatively and at 3 and 6 months postoperatively. Main outcome measures were keratocyte density and maximum anterior stromal light reflectivity. RESULTS:Mean epithelial healing time was 3.2±0.4 and 3.0±0.3 days in the mechanical and alcohol-assisted groups, respectively (P=.001). Anterior retroablation stromal keratocyte density was 704.3±119.9 cells/mm(2) and 734.3±103.7 cells/mm(2) at 3 months (P=.05) and 643.8±134.4 cells/mm(2) and 696.7±129.6 cells/mm(2) at 6 months (P=.02) in the mechanical and alcohol-assisted groups, respectively. No significant difference was noted in midstromal and posterior keratocyte density between the two groups. Maximum reflectivity was 61.56±12.64 international units (IU) and 56.93±7.86 IU in the mechanical and alcohol-assisted groups, respectively, 3 months after surgery (P=.018). Corresponding values were 49.46±4.97 IU and 48.98±4.60 IU, respectively, 6 months after surgery (P=.628). CONCLUSIONS:Due to more adverse effects of mechanical epithelial debridement on anterior keratocyte density and anterior stromal reflectivity, alcohol-assisted epithelial debridement is recommended as the procedure of choice for epithelial removal during PRK in patients with mild myopia. |
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Authors:
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Bahram Einollahi; Alireza Baradaran-Rafii; Mozhgan Rezaei-Kanavi; Medi Eslani; Mohammad-Reza Parchegani; Mohammad Zare; Sepehr Feizi; Farid Karimian |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-31 |
Journal Detail:
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Title: Journal of refractive surgery (Thorofare, N.J. : 1995) Volume: - ISSN: 1081-597X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505927 Medline TA: J Refract Surg Country: - |
Other Details:
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Languages: ENG Pagination: 1-7 Citation Subset: - |
Copyright Information:
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Copyright 2011, SLACK Incorporated. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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