Document Detail


Mechanical ventilation of newborns infant changes in plasma pro- and anti-inflammatory cytokines.
MedLine Citation:
PMID:  19783005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate plasma levels of interleukin (IL)-1beta, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-alpha in newborn infants immediately before and after 2 hours of mechanical ventilation. STUDY DESIGN: Term and late preterm neonates with no history of mechanical ventilation and/or ventilatory support were studied prospectively. Exclusion criteria were congenital malformations, congenital infections, use of nitric oxide, resuscitation with positive-pressure ventilation, and any procedure in the delivery room or neonatal intensive care unit that resulted in tracheal intubation. Blood samples for IL-1beta, IL-6, IL-8, IL-10, and TNF-alpha levels were collected before intubation and mechanical ventilation and 2 hours later. RESULTS: Nineteen newborn infants with gestational age 35.8 +/- 1.9 weeks and birth weight 2280 +/- 370 g were included. Pro-inflammatory cytokines increased: IL-8 (2.5-fold), IL-1beta (7.5-fold), and TNF-alpha (10-fold), and the anti-inflammatory cytokine IL-10 decreased by 90%. Although median IL-6 levels were similar between before and after ventilation, IL-6 increased in 89.4% of infants. CONCLUSIONS: A short period of mechanical ventilation promotes an imbalance of plasma levels of pro-inflammatory and anti-inflammatory cytokines. The systemic alteration of cytokines in response to mechanical ventilation may lead to ventilator-induced lung injury.
Authors:
Betania Bohrer; Rita C Silveira; Eurico C Neto; Renato S Procianoy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  156     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Universidade Federal do Rio Grande do Sul, and Newborn Section, Hospital de Cl?nicas de Porto Alegre, Porto Alegre, RS, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Humans
Infant, Newborn
Interleukin-10 / blood
Interleukin-1beta / blood
Interleukin-6 / blood
Interleukin-8 / blood
Interleukins / blood*
Oxygen / blood
Positive-Pressure Respiration
Prospective Studies
Respiration, Artificial* / adverse effects
Tumor Necrosis Factor-alpha / blood*
Ventilator-Induced Lung Injury / blood
Chemical
Reg. No./Substance:
0/Interleukin-1beta; 0/Interleukin-6; 0/Interleukin-8; 0/Interleukins; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 7782-44-7/Oxygen

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