Document Detail


Mechanical function of vertebral body osteophytes, as revealed by experiments on cadaveric spines.
MedLine Citation:
PMID:  20683388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY DESIGN: Mechanical testing of cadaveric spines.
OBJECTIVE: To determine whether vertebral body osteophytes act primarily to reduce compressive stress on the intervertebral discs, or to stabilize the spine in bending.
SUMMARY OF BACKGROUND DATA: The mechanical significance of vertebral osteophytes is unclear.
METHODS: Thoracolumbar spines were obtained from cadavers, aged 51 to 92 years, with vertebral body osteophytes, mostly anterolateral. Twenty motion segments, from T5-T6 to L3-L4, were loaded in compression to 1.5 kN, and then in flexion, extension, and lateral bending to 10 to 25 Nm (depending on specimen size) with a compressive preload. Vertebral movements were tracked using an optical 2-dimensional MacReflex system. Tests were performed in random order, and were repeated after excision of all osteophytes. Osteophyte function was inferred from (a) changes in the force or moment resisted and (b) changes in tangent stiffness, measured at maximum displacement or rotation angle. Volumetric bone mineral density (BMD) was measured using dual photon x-ray absorptiometry and water immersion. Results were analyzed using repeated measures analysis of variance.
RESULTS: Resistance to compression was reduced by an average of 17% after osteophyte removal (P < 0.05), and resistance to bending moment in flexion, extension, and left and right lateral bending was reduced by 49%, 36%, 36%, and 35%, respectively (all P < 0.01). Changes in tangent stiffness were similar. Osteophyte removal increased the neutral zone in bending (P < 0.05) and, on average, reduced motion segment BMD by 7% to 9%. Results were insensitive to applied loads and moments, but several changes were proportional to osteophyte size.
CONCLUSION: Vertebral body osteophytes resist bending movements more than compression. Because they reverse the instability in bending that can stimulate their formation, these osteophytes seem to be adaptive rather than degenerative. Results suggest that osteophytes could cause clinical BMD measurements to underestimate vertebral compressive strength.
Authors:
Maimouna Al-Rawahi; Jin Luo; Phillip Pollintine; Patricia Dolan; Michael A Adams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Spine     Volume:  36     ISSN:  1528-1159     ISO Abbreviation:  Spine     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-20     Completed Date:  2011-08-30     Revised Date:  2011-12-01    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  770-7     Citation Subset:  IM    
Affiliation:
Sultan Qaboos University Hospital, Sultanate of Oman.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biomechanics
Bone Density
Cadaver
Compressive Strength
Female
Humans
Intervertebral Disc / physiopathology*
Lumbar Vertebrae / physiopathology*
Male
Middle Aged
Osteophyte / physiopathology*
Range of Motion, Articular
Spinal Osteophytosis / physiopathology*
Stress, Mechanical
Thoracic Vertebrae / physiopathology*
Grant Support
ID/Acronym/Agency:
//Arthritis Research UK

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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