Document Detail

Mechanical buckling of veins under internal pressure.
MedLine Citation:
PMID:  20094913     Owner:  NLM     Status:  MEDLINE    
Venous tortuosity is associated with multiple disease states and is often thought to be a consequence of venous hypertension and chronic venous disease. However, the underlying mechanisms of vein tortuosity are unclear. We hypothesized that increased pressure causes vein buckling that leads to a tortuous appearance. The specific aim of this study was to determine the critical buckling pressure of veins. We determined the buckling pressure of porcine jugular veins and measured the mechanical properties of these veins. Our results showed that the veins buckle when the transmural pressure exceeds a critical pressure that is strongly related to the axial stretch ratio in the veins. The critical pressures of the eight veins tested were 14.2 +/- 5.4 and 26.4 +/- 9.0 mmHg at axial stretch ratio 1.5 and 1.7, respectively. In conclusion, veins buckle into a tortuous shape at high lumen pressures or reduced axial stretch ratios. Our results are useful in understanding the development of venous tortuosity associated with varicose veins, venous valvular insufficiency, diabetic retinopathy, and vein grafts.
Ricky Martinez; Cesar A Fierro; Paula K Shireman; Hai-Chao Han
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-01-22
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-30     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1345-53     Citation Subset:  IM    
Department of Mechanical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
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MeSH Terms
Blood Pressure / physiology
Computer Simulation
Elastic Modulus
Jugular Veins / physiology*
Models, Cardiovascular*
Shear Strength / physiology
Stress, Mechanical
Vascular Resistance / physiology
Vasodilation / physiology
Grant Support
HL074236/HL/NHLBI NIH HHS; HL095852/HL/NHLBI NIH HHS; R01 HL074236-06/HL/NHLBI NIH HHS; R01 HL095852-01A1/HL/NHLBI NIH HHS; R01 HL095852-02/HL/NHLBI NIH HHS; R01 HL095852-03/HL/NHLBI NIH HHS

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