Document Detail


Mechanical buckling of veins under internal pressure.
MedLine Citation:
PMID:  20094913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Venous tortuosity is associated with multiple disease states and is often thought to be a consequence of venous hypertension and chronic venous disease. However, the underlying mechanisms of vein tortuosity are unclear. We hypothesized that increased pressure causes vein buckling that leads to a tortuous appearance. The specific aim of this study was to determine the critical buckling pressure of veins. We determined the buckling pressure of porcine jugular veins and measured the mechanical properties of these veins. Our results showed that the veins buckle when the transmural pressure exceeds a critical pressure that is strongly related to the axial stretch ratio in the veins. The critical pressures of the eight veins tested were 14.2 +/- 5.4 and 26.4 +/- 9.0 mmHg at axial stretch ratio 1.5 and 1.7, respectively. In conclusion, veins buckle into a tortuous shape at high lumen pressures or reduced axial stretch ratios. Our results are useful in understanding the development of venous tortuosity associated with varicose veins, venous valvular insufficiency, diabetic retinopathy, and vein grafts.
Authors:
Ricky Martinez; Cesar A Fierro; Paula K Shireman; Hai-Chao Han
Related Documents :
1188433 - Glaucoma with elevated episcleral venous pressure.
17322113 - Venous hemodynamic responses to acute temperature increase in the rainbow trout (oncorh...
22458203 - Coming through when it matters most.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-01-22
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-30     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1345-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Computer Simulation
Elastic Modulus
Jugular Veins / physiology*
Models, Cardiovascular*
Pressure
Shear Strength / physiology
Stress, Mechanical
Swine
Vascular Resistance / physiology
Vasodilation / physiology
Grant Support
ID/Acronym/Agency:
HL074236/HL/NHLBI NIH HHS; HL095852/HL/NHLBI NIH HHS; R01 HL074236/HL/NHLBI NIH HHS; R01 HL074236-06/HL/NHLBI NIH HHS; R01 HL095852/HL/NHLBI NIH HHS; R01 HL095852-01A1/HL/NHLBI NIH HHS; R01 HL095852-02/HL/NHLBI NIH HHS; R01 HL095852-03/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  New lines of GFP transgenic rats relevant for regenerative medicine and gene therapy.
Next Document:  On the left ventricular vortex reversal after mitral valve replacement.