Document Detail


Mechanical buckling of arterioles in collateral development.
MedLine Citation:
PMID:  23034307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Collateral arterioles enlarge in both diameter and length, and develop corkscrew-like tortuous patterns during remodeling. Recent studies showed that artery buckling could lead to tortuosity. The objective of this study was to determine arteriole critical buckling pressure and buckling pattern during arteriole remodeling. Arterioles were modeled as elastic cylindrical vessels with an elastic matrix support and underwent axial and radial growth. Our results demonstrated that arteriole critical buckling pressure decreased with increasing axial growth ratio and radius growth ratio, but increased with increasing wall thickness. Arteriole buckling mode number increased (wavelength decreased) with increasing axial growth ratio, but decreased with increasing radius growth ratio and wall thickness. Our study suggests that axial growth in arterioles makes them prone to buckling and that buckling leads to tortuous collaterals. These results shed light on the mechanism of collateral arteriole tortuosity.
Authors:
Qin Liu; Hai-Chao Han
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-09-30
Journal Detail:
Title:  Journal of theoretical biology     Volume:  316     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-04-24     Revised Date:  2014-01-16    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  42-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Arterioles / growth & development*,  physiology*
Blood Pressure / physiology
Collateral Circulation / physiology*
Computer Simulation
Humans
Models, Cardiovascular
Pressure
Stress, Mechanical*
Tunica Intima / physiology
Vasoconstriction / physiology
Vasodilation / physiology*
Grant Support
ID/Acronym/Agency:
R01 HL095852/HL/NHLBI NIH HHS; R01HL095852/HL/NHLBI NIH HHS
Comments/Corrections

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