| Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in rats. | |
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MedLine Citation:
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PMID: 20530708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Processed meat intake is associated with colorectal cancer risk, but no experimental study supports the epidemiologic evidence. To study the effect of meat processing on carcinogenesis promotion, we first did a 14-day study with 16 models of cured meat. Studied factors, in a 2 x 2 x 2 x 2 design, were muscle color (a proxy for heme level), processing temperature, added nitrite, and packaging. Fischer 344 rats were fed these 16 diets, and we evaluated fecal and urinary fat oxidation and cytotoxicity, three biomarkers of heme-induced carcinogenesis promotion. A principal component analysis allowed for selection of four cured meats for inclusion into a promotion study. These selected diets were given for 100 days to rats pretreated with 1,2-dimethylhydrazine. Colons were scored for preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF). Cured meat diets significantly increased the number of ACF/colon compared with a no-meat control diet (P = 0.002). Only the cooked nitrite-treated and oxidized high-heme meat significantly increased the fecal level of apparent total N-nitroso compounds (ATNC) and the number of MDF per colon compared with the no-meat control diet (P < 0.05). This nitrite-treated and oxidized cured meat specifically increased the MDF number compared with similar nonnitrite-treated meat (P = 0.03) and with similar nonoxidized meat (P = 0.004). Thus, a model cured meat, similar to ham stored aerobically, increased the number of preneoplastic lesions, which suggests colon carcinogenesis promotion. Nitrite treatment and oxidation increased this promoting effect, which was linked with increased fecal ATNC level. This study could lead to process modifications to make nonpromoting processed meat. |
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Authors:
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Raphaëlle L Santarelli; Jean-Luc Vendeuvre; Nathalie Naud; Sylviane Taché; Françoise Guéraud; Michelle Viau; Claude Genot; Denis E Corpet; Fabrice H F Pierre |
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Publication Detail:
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Type: Journal Article Date: 2010-06-08 |
Journal Detail:
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Title: Cancer prevention research (Philadelphia, Pa.) Volume: 3 ISSN: 1940-6215 ISO Abbreviation: Cancer Prev Res (Phila) Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-08-30 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101479409 Medline TA: Cancer Prev Res (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 852-64 Citation Subset: IM |
Copyright Information:
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2010 AACR. |
Affiliation:
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Université de Toulouse, ENVT, INRA, UMR Xénobiotiques, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / metabolism, urine Colonic Neoplasms / etiology* Cooking Diet / adverse effects Feces / chemistry Female Heme / toxicity Meat / toxicity* Meat-Packing Industry Models, Animal Mucins / metabolism* Nitrites / toxicity* Precancerous Conditions / etiology* Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Mucins; 0/Nitrites; 14875-96-8/Heme |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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