Document Detail


Measuring the weight of the isolated perfused rat lung during negative pressure ventilation.
MedLine Citation:
PMID:  7640394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Weight measurement represents a means of quantitating edema formation in isolated lungs and following its time course. During ventilation by negative pressure measurements with commonly used weight transducers are impossible because the pressure changes inside the artificial thoracic chamber affect the weight reading. Therefore, we have developed a weight transducer that can be used during negative pressure ventilation. Its design and applicability for assessing weight gain induced by various agents in the negative-pressure-ventilated isolated perfused rat lung is presented here.
Authors:
S Uhlig; O Heiny
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacological and toxicological methods     Volume:  33     ISSN:  1056-8719     ISO Abbreviation:  J Pharmacol Toxicol Methods     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-09-21     Completed Date:  1995-09-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9206091     Medline TA:  J Pharmacol Toxicol Methods     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Affiliation:
Department of Biochemical Pharmacology, University of Konstanz, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Lung / anatomy & histology*,  physiopathology
Organ Size
Pulmonary Edema / diagnosis*,  physiopathology
Pulmonary Ventilation
Rats
Rats, Wistar
Tidal Volume
Time Factors
Transducers
Ventilators, Negative-Pressure*

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