| Measuring venous blood volume changes during activation using hyperoxia. | |
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MedLine Citation:
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PMID: 22146751 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study describes a novel method for measuring relative changes in venous cerebral blood volume (CBVv) using hyperoxia as a contrast agent. This method exploits the extravascular BOLD effect and its dependency on both task-related activation induced changes in venous blood oxygenation and changes due to breathing an oxygen enriched gas mixture. Changes in CBVv on activation can be estimated by comparing the change in transverse relaxation rate, R(2)(⁎), due to hyperoxia in both baseline and activation states. Furthermore these measurements can be converted into a measure of the percentage change in CBVv. Experiments were performed to measure changes in a CBVv-weighted signal in response to a simple motor task. Both positive and negative changes in CBVv-weighted signal were detected in the positively activated BOLD region. |
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Authors:
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N P Blockley; I D Driver; J A Fisher; S T Francis; P A Gowland |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-22 |
Journal Detail:
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Title: NeuroImage Volume: - ISSN: 1095-9572 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Functional Magnetic Resonance Imaging, Department of Radiology, University of California San Diego, La Jolla, CA, USA; Sir Peter Mansfield Magnetic Resonance, School of Physics and Astronomy, University of Nottingham, Nottingham, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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