Document Detail

Measuring and using light in the melanopsin age.
MedLine Citation:
PMID:  24287308     Owner:  NLM     Status:  MEDLINE    
Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythm disruption. These biological and behavioral effects of light are influenced by a distinct photoreceptor in the eye, melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), in addition to conventional rods and cones. We summarize the neurophysiology of this newly described sensory pathway and consider implications for the measurement, production, and application of light. A new light-measurement strategy taking account of the complex photoreceptive inputs to these non-visual responses is proposed for use by researchers, and simple suggestions for artificial/architectural lighting are provided for regulatory authorities, lighting manufacturers, designers, and engineers.
Robert J Lucas; Stuart N Peirson; David M Berson; Timothy M Brown; Howard M Cooper; Charles A Czeisler; Mariana G Figueiro; Paul D Gamlin; Steven W Lockley; John B O'Hagan; Luke L A Price; Ignacio Provencio; Debra J Skene; George C Brainard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-11-25
Journal Detail:
Title:  Trends in neurosciences     Volume:  37     ISSN:  1878-108X     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-01-03     Completed Date:  2014-08-28     Revised Date:  2014-10-28    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Circadian Rhythm / physiology
Photoreceptor Cells / metabolism
Phototherapy / trends*
Retinal Ganglion Cells / metabolism
Rod Opsins / physiology*
Grant Support
BB/I007296/1//Biotechnology and Biological Sciences Research Council; BB/I017836/1//Biotechnology and Biological Sciences Research Council; BB/K002252/1//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Rod Opsins; 0/melanopsin

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