Document Detail


Measuring reward assessment in a semi-naturalistic context: the effects of selective amygdala, orbital frontal or hippocampal lesions.
MedLine Citation:
PMID:  17693034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studying the neural mechanisms underlying complex goal-directed behaviors, such as social behavior, reward seeking or punishment avoidance, has become increasingly tractable in humans, nonhuman primates and rodents. In most experiments, however, goal-directed behaviors are measured in a laboratory setting, which is vastly different from the context in which these behaviors naturally occur. This study adapted a reward assessment paradigm, previously conducted with rhesus monkeys (Macaca mulatta) in the controlled environment of a Wisconsin General Testing Apparatus (WGTA) [Machado CJ, Bachevalier J (2007) The effects of selective amygdala, orbital frontal cortex or hippocampal formation lesions on reward assessment in nonhuman primates. Eur J Neurosci 25:2885-2904], to a more naturalistic context. We used this new paradigm to examine the effects of bilateral amygdaloid, hippocampal or orbital frontal cortex lesions on established food and nonfood preferences. Behavioral modification following reinforcer devaluation was also measured. Consistent with our previous study, none of the lesions produced changes in preference for palatable foods relative to pre-surgery, but animals with amygdala lesions displayed heightened preference for unpalatable foods that control or other operated animals typically avoided. In contrast to several previous WGTA-based experiments, nonfood preference was not affected by any of the lesions. Finally, animals with orbital frontal cortex lesions continued to select preferred foods after satiation, but those with amygdala, hippocampal or sham lesions altered their foraging behavior appropriately and selected less of the sated food. These findings parallel food devaluation results obtained with these same animals when tested in the WGTA. Overall, this study stresses the importance of testing context when measuring decision-making abilities in nonhuman primates with selective brain lesions.
Authors:
C J Machado; J Bachevalier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-08-10
Journal Detail:
Title:  Neuroscience     Volume:  148     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2008-01-11     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  599-611     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amygdala / anatomy & histology,  physiology*
Animals
Behavior, Animal / physiology
Brain Injuries / physiopathology,  psychology
Decision Making / physiology*
Denervation
Feeding Behavior / physiology
Goals
Hippocampus / anatomy & histology,  physiology*
Macaca mulatta
Male
Neuropsychological Tests / standards
Prefrontal Cortex / anatomy & histology,  physiology*
Reinforcement (Psychology)
Reward*
Species Specificity
Grant Support
ID/Acronym/Agency:
F31 MH063577-03/MH/NIMH NIH HHS; HD-35471/HD/NICHD NIH HHS; MH-58846/MH/NIMH NIH HHS; MH-63577/MH/NIMH NIH HHS; P01 HD035471/HD/NICHD NIH HHS; P01 HD035471-030003/HD/NICHD NIH HHS; P51 RR000165/RR/NCRR NIH HHS; P51 RR000165-465376/RR/NCRR NIH HHS; R01 MH058846/MH/NIMH NIH HHS; R01 MH058846-05/MH/NIMH NIH HHS; RR00165/RR/NCRR NIH HHS
Comments/Corrections

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