| Measuring perfusion and permeability in renal cell carcinoma with dynamic contrast-enhanced MRI: a pilot study. | |
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MedLine Citation:
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PMID: 20099364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To retrospectively assess an improved quantitative methodology with separate assessment of perfusion and permeability for characterization of primary renal cell carcinoma (RCC) and monitoring antiangiogenic treatment. MATERIALS AND METHODS: Fifteen RCC patients before surgery, 6 RCC patients before and after neoadjuvant antiangiogenic therapy, and 15 patients without renal disease underwent dynamic contrast-enhanced (DCE)-MRI of the kidney with integrated retrospective respiratory triggering and an individual arterial input function. Tracer kinetic analysis was performed with a two-compartment-filtration-model for the kidney data and a two-compartment-exchange-model for the tumor data, providing four independent parameters: the perfusion-parameters plasma flow (F(P)) and plasma volume (V(P)), and the permeability-parameters extraction flow (F(E)) and extravascular-extracellular volume (V(E)). RESULTS: In tumors F(P) and F(E) were significantly lower than in normal kidneys. Tracer kinetic analysis displayed hemodynamic alteration caused by vessel infiltration or necrosis. Papillary RCC could be differentiated from clear-cell variants by a distinct perfusion pattern. In antiangiogenically treated RCC V(E) was not significantly decreased, while the perfusion parameters V(P) and F(P) were significantly diminished. CONCLUSION: DCE-MRI with integrated motion compensation enables evaluation of primary RCC and detects distinct perfusion patterns. Quantification with a two-compartment-exchange-model produces a separate perfusion- and permeability characterization and may become a diagnostic tool to monitor antiangiogenic treatment. |
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Authors:
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Mike Notohamiprodjo; Steven Sourbron; Michael Staehler; Henrik J Michaely; Ulrike I Attenberger; Gerwin P Schmidt; Holger Boehm; Annie Horng; Christian Glaser; Christian Stief; Maximilian F Reiser; Karin A Herrmann |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 31 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 490-501 Citation Subset: IM |
Affiliation:
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Department of Clinical Radiology, University Hospitals Munich, Campus Grosshadern, Munich, Germany. mike.notohamiprodjo@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Carcinoma, Renal Cell / diagnosis*, physiopathology*, therapy Humans Kidney Neoplasms / diagnosis*, physiopathology*, therapy Magnetic Resonance Imaging / methods* Permeability Pilot Projects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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