| Measuring the integrity of the human blood-brain barrier using magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 21082374 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The evaluation of blood-brain barrier (BBB) integrity with contrast-enhanced magnetic resonance imaging (MRI) may prove valuable in the setting of certain brain pathologies, such as brain tumors and acute ischemic stroke. Various MRI protocols have been developed to explore the integrity of the BBB by monitoring the leakage of intravenously administered contrast medium into the brain parenchyma. In its simplest form, BBB integrity is assessed qualitatively, by determining the presence or absence of contrast-enhancement on a structural MR image. When a dynamic contrast-enhanced (DCE) MRI protocol is combined with a suitable pharmacokinetic model, DCE-MRI can map the spatial distribution of BBB integrity throughout the brain and assist with evaluating the effects of therapy. Several model-free surrogate measures of BBB permeability have been recently proposed, all of which can be readily computed from standard dynamic susceptibility contrast MRI perfusion scans. Contrast-enhanced MRI offers multiple strategies for evaluating BBB integrity. |
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Authors:
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Andrea Kassner; Rebecca Thornhill |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 686 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 229-45 Citation Subset: IM |
Affiliation:
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Department of Medical Imaging, University of Toronto, Toronto, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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