Document Detail


Measuring the human T cell receptor gamma-chain locus.
MedLine Citation:
PMID:  3498213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human T cell receptor gamma locus, including eleven variable-region, five joining-region, and two constant-region segments, is contained in 160 kilobases. During T cell somatic development these genes undergo rearrangement by deletion of the sequences separating the variable and joining regions. The molecular map of this locus was completely defined by deletion mapping and restriction mapping. Restriction fragments were resolved by standard agarose electrophoresis and field inversion electrophoresis. These studies demonstrate that the deletions in this locus, which occur during the formation of a functional T cell receptor gamma-chain gene, range from 50 to 145 kilobases in length. These studies also provide a structural basis for understanding the development of the gamma-chain peptide repertoire, and extends the potential of the emerging pulsed-field electrophoretic technology.
Authors:
W M Strauss; T Quertermous; J G Seidman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  237     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-06     Completed Date:  1987-10-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1217-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Chromosome Deletion
Genes*
Humans
Linkage (Genetics)
Macromolecular Substances
Receptors, Antigen, T-Cell / genetics*
T-Lymphocytes / immunology*
Grant Support
ID/Acronym/Agency:
AI18436/AI/NIAID NIH HHS; T32-07208//PHS HHS
Chemical
Reg. No./Substance:
0/Macromolecular Substances; 0/Receptors, Antigen, T-Cell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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