| Measuring hemodynamics in the developing heart tube with four-dimensional gated Doppler optical coherence tomography. | |
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MedLine Citation:
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PMID: 21198196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemodynamics is thought to play a major role in heart development, yet tools to quantitatively assess hemodynamics in the embryo are sorely lacking. The especially challenging analysis of hemodynamics in the early embryo requires new technology. Small changes in blood flow could indicate when anomalies are initiated even before structural changes can be detected. Furthermore, small changes in the early embryo that affect blood flow could lead to profound abnormalities at later stages. We present a demonstration of 4-D Doppler optical coherence tomography (OCT) imaging of structure and flow, and present several new hemodynamic measurements on embryonic avian hearts at early stages prior to the formation of the four chambers. Using 4-D data, pulsed Doppler measurements could accurately be attained in the inflow and outflow of the heart tube. Also, by employing an en-face slice from the 4-D Doppler image set, measurements of stroke volume and cardiac output are obtained without the need to determine absolute velocity. Finally, an image plane orthogonal to the blood flow is used to determine shear stress by calculating the velocity gradient normal to the endocardium. Hemodynamic measurements will be crucial to identifying genetic and environmental factors that lead to congenital heart defects. |
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Authors:
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Michael W Jenkins; Lindsy Peterson; Shi Gu; Madhusudhana Gargesha; David L Wilson; Michiko Watanabe; Andrew M Rollins |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of biomedical optics Volume: 15 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-05-31 Revised Date: 2011-12-13 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 066022 Citation Subset: IM |
Affiliation:
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Case Western Reserve University, Department of Pediatrics Cleveland, OH 44106, USA. mwj5@case.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / physiology Cardiac Output / physiology Coronary Circulation / physiology Heart / anatomy & histology, embryology*, physiology* Laser-Doppler Flowmetry / methods* Quail / embryology*, physiology* Respiratory-Gated Imaging Techniques / methods* Tomography, Optical Coherence / methods* |
| Grant Support | |
ID/Acronym/Agency:
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C06RR12463-01/RR/NCRR NIH HHS; R01 HL095717/HL/NHLBI NIH HHS; R01-HL083048/HL/NHLBI NIH HHS; T32HD007104/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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