| Measuring exhaled nitric oxide at high altitude. | |
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MedLine Citation:
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PMID: 19524073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The altitude performance of two NO analysers using different NO detectors was studied. The analysers and their flow regulators were tested with simulated exhalations of reference gases. At 4000 m, volume flow was +35% and mass flow -24% of nominal in both instruments. The reduced mass flow increased the exhaled NO fraction by 26% for a given rate of NO excretion. Furthermore, the electrochemical NO detector in one analyser showed an increased signal level for a given partial pressure of test gas. Taken together, these two effects increased the signal output by 60% in comparison to the NO partial pressure. To avoid the above errors, it is proposed that the flow regulator should be readjusted to give a volume flow of 50 ml s(-1) at the altitude of interest and that the analyser should be recalibrated to the operational altitude. Finally, it is recommended that exhaled NO should always be reported as partial pressure and not as volume fraction, in order to compare measurements at any altitude. |
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Authors:
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Tryggve Hemmingsson; Astrid Horn; Dag Linnarsson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-11 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 167 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-22 Completed Date: 2009-09-29 Revised Date: 2010-02-17 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 292-8 Citation Subset: IM |
Affiliation:
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Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. tryggve.hemmingsson@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pressure Algorithms Altitude* Calibration Electrochemistry Guidelines as Topic Humans Luminescence Nitric Oxide / analysis*, metabolism* Positive-Pressure Respiration Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
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Respir Physiol Neurobiol. 2010 Jan 31;170(1):1-2; author reply 3-4
[PMID:
19922816
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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